Results 81 to 90 of about 613,936 (286)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Circuits as Graphs: A Review of Graph Learning for Secure and Trustworthy Hardware

open access: yesIEEE Access
Modern Integrated Circuits (ICs) are highly interconnected, making graph representation a natural foundation for hardware security analysis. In recent years, graph-based approaches have gained significant traction in addressing a wide range of hardware ...
Afjal Hossan Sarower   +2 more
doaj   +1 more source

Federal Ocean Programs: Good for the Economy [PDF]

open access: yes, 2012
The marine resources of the United States provide vast economic returns on investments. As illustrated by the graph below, the gross domestic product from industries that depend on the oceans far exceeds federal expenditures for ocean and coastal ...

core  

Protecting Privacy in Knowledge Graphs With Personalized Anonymization

open access: yesIEEE Transactions on Dependable and Secure Computing
Knowledge graphs (KGs) are emerging data models allowing data providers to share data. This data sharing might bring new knowledge and collaborations, with evident benefits for providers. However, since KGs might contain sensitive information about users, it is of utmost importance to ensure KG anonymization before publishing.
Anh-Tu Hoang   +2 more
openaire   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Large-Scale Dynamic Social Network Directed Graph K-In&Out-Degree Anonymity Algorithm for Protecting Community Structure

open access: yesIEEE Access, 2019
Social network data publishing is dynamic, and attackers can perform association attacks based on social network directed graph data at different times.
Xiaolin Zhang   +3 more
doaj   +1 more source

Protection of Graphs. Generic results with emphasis on Cartesian and Lexicographic product of graphs

open access: yes, 2020
Suppose that one or more entities are stationed at some of the vertices of a graph G and that an entity at a vertex can deal with a problem at any vertex in its closed neighbourhood. Informally, we say that G is protected under a given placement of entities if there exists at least one entity available to handle a problem at any vertex. Cockayne et al.
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Differential privacy protection scheme based on edge betweenness model

open access: yesTongxin xuebao, 2019
With the continuous development of social network application,user’s personal social data is so sensitive that the problem of privacy protection needs to be solved urgently.In order to reduce the network data sensitivity,a differential privacy protection
Haiping HUANG   +3 more
doaj   +2 more sources

Collective knowledge graph: meta knowledge transfer and federated graph reasoning

open access: yes智能科学与技术学报, 2022
Collective knowledge graphs refer to knowledge graphs that are managed and maintained in a decentralized or distributed manner through group collaboration.Compared with the existing centrally managed knowledge graph, the collective knowledge graph has ...
Mingyang CHEN   +4 more
doaj  

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