Results 61 to 70 of about 1,392,860 (268)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Construction of industry knowledge graph based on graph theory
大数据, 2023 China has the largest industrial scale and the most abundant industry type among the world.However, due to the influence of many factors, it is necessary to discover the blocking and breakpoints of the industrial chain, identify the stuck points, find ...
Zhenjun LI +6 more
doaj
Connectedness of graphs and its application to connected matroids through covering-based rough sets [PDF]
, 2015 Graph theoretical ideas are highly utilized by computer science fields especially data mining. In this field, a data structure can be designed in the form of tree.
Huang, Aiping, Zhu, William
core
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Chip-firing games on Eulerian digraphs and NP-hardness of computing the rank of a divisor on a graph
, 2015 Baker and Norine introduced a graph-theoretic analogue of the Riemann-Roch theory. A central notion in this theory is the rank of a divisor. In this paper we prove that computing the rank of a divisor on a graph is NP-hard.
Kiss, Viktor, Tóthmérész, Lilla
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Tur\'an Graphs, Stability Number, and Fibonacci Index
, 2008 The Fibonacci index of a graph is the number of its stable sets. This parameter is widely studied and has applications in chemical graph theory. In this paper, we establish tight upper bounds for the Fibonacci index in terms of the stability number and ...
A. Knopfmacher +20 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Discrete Signal Processing on Graphs: Sampling Theory
, 2015 We propose a sampling theory for signals that are supported on either directed or undirected graphs. The theory follows the same paradigm as classical sampling theory.
Chen, Siheng +3 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source