Results 71 to 80 of about 279,040 (261)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Big Data and IT Network Data Visualization [PDF]
International Journal of Mathematical, Engineering and Management Sciences, 2018 Visualization with graphs is popular in the data analysis of Information Technology (IT) networks or computer networks. An IT network is often modelled as a graph with hosts being nodes and traffic being flows on many edges. General visualization methods
Lidong Wang
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Spherical Layout for 3D Graph Visualization
Journal of Computer Science and Technology, 2007 The goal of this work was centered in the graph visualization. The hope is that the extra dimension would give, literally, more space, and that this would ease the problem of displaying large structures.
Martín Leonardo Larrea
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Direct Visual Editing of Node Attributes in Graphs
Informatics, 2016 There are many expressive visualization techniques for analyzing graphs. Yet, there is only little research on how existing visual representations can be employed to support data editing.
Christian Eichner +3 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Embedding, Clustering and Coloring for Dynamic Maps
Journal of Graph Algorithms and Applications, 2014 We describe a practical approach for visualizing multiple relationships defined on the same dataset using a geographic map metaphor, where clusters of nodes form countries and neighboring countries correspond to nearby clusters. Our aim is to provide
Yifan Hu +2 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Graph Visualization Tools: A Comparative Analysis
JISR on Computing, 2015 Data visualization is becoming a necessity for big organizations as the social networking data is growing rapidly. It is becoming difficult to visualize data and perform complex comparisons.
Fariha Majeed, Saif-ur-Rahman
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