Results 81 to 90 of about 200,163 (265)
GRAPHIC AND MEANING IN LOGO DESIGN
Journal of Industrial Design and Engineering GraphicsTo design a logo is a special work. It means creation, intelligence, use of colors, and of course, signs and symbols. It is about a visual personality and a signature of an entity. During the working process, a designer has to answer to a few questions,
Victor ADIR +2 more
doaj +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
TİPOGRAFİK TASARIMDA RENGİN OKUNURLUĞA ETKİSİ KONUSUNDA ÖĞRENCİ GÖRÜŞLERİNİN İNCELENMESİ
Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2017 Çağımızda iletişim kurmak için birçok iletişim dili ve farklı iletişim teknikleri geliştirilmiştir ve bu dillerin sayısı her geçen gün biraz daha artmaktadır.
Mustafa Kınık, Mahmut Sami Öztürk
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Studia Universitatis Babeş-Bolyai. Musica, 2014 Geo Goidaci was born in 14th of March 1947, in Northern Transylvania (Iojib, Satu-Mare). He graduated The Fine Arts High-school of Cluj, and also, the sculpture department of the Institute of Fine Arts “Ion Andreescu” from the same town.
Gabriela Coca
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Scientific ReportsAddressing the challenges of observing and detecting defects on ordinary glass surfaces, this paper proposes a defect detection method combining shadowgraphy technology with the YOLO_FSA algorithm.
Yulu Xue +5 more
doaj +1 more source