Results 51 to 60 of about 846,152 (303)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

GLBTQ content in comics/graphic novels for teens [PDF]

open access: yes, 2007
Purpose – This paper aims to provide an historical perspective and current guidance for youth librarians collecting graphic novels for teens. Design/methodology/approach – The paper provides a brief review of the historical issues involved with ...
Greyson, Devon
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

The Children\u27s Community Center [PDF]

open access: yes, 2017
We are the Children’s Community Center, a NGO thats wants to provide an emergency response to the new surge of Rohingya refugee children. We want to relieve the daily mental traumas of the refugee camps through the collaborative interaction of the ...
Aldana (Graphic Design Certificate), Silvia Martin   +3 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Presentation techniques in contemporary graphic design

open access: yesJournal of Architecture, Art & Humanistic Science
The research deals with the concept of the process of presentation in contemporary graphic design, how to employ it in graphic designs and its role as well in its formative and semiotic construction in terms of deconstructing the structures and visual ...
Asst. Prof. Dr. Ahmed Gamal Ahmed Eid Assistant Professor of Graphic Design and former Head of the GraAsst. Prof. Dr. Ahmed Gamal Ahmed Eid Assistant Professor of Graphic Design and former Head of the Graphic Design Department, Faculty of Fine Arts, Luxor Universityphic Design Department, Faculty of Fine Arts, Luxor University
doaj   +1 more source

Solving Problem of Thermal Conduction for Providing Strength of Electronic Units on Thermal Impacts

open access: yesMATEC Web of Conferences, 2016
Paper represents new approach to physical and mathematical modeling of thermal fields distribution in sealed electronic units on the base of introducing “effective parameters” of the system.
Petrashchuk Svitlana   +2 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

MURAL AND GRAFITTI APPLICATION ON HOSTEL INTERIOR DESIGN [PDF]

open access: yes, 2019
Hostel gains its popularity due to the rapid growth of urban tourism in Indonesia. The hostel not only offers afforda- ble accommodation, but it also has a more innovative design.
Rahardjo, S. (Setiamurti )   +1 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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