Results 31 to 40 of about 55,461 (257)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
img journalThis article discusses the role of images in archaeological disciplines and the contribution that graphic sciences can make to research in this subject area.
Enrico Cicalò, Michele Valentino
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
HOW TO ACHIEVE A GRAPHIC LANGUAGE IN A SIGNAGE SYSTEM
Journal of Industrial Design and Engineering Graphics, 2015 This paper presents the importance of a signage system to inform and guide with a purpose: to make useful an activity. It is a special role of graphics to connect people to a system which has to be clear and legible. Along our researches in this field we
ADÎR Victor +2 more
doaj
“El Plato del Bien Comer”, ¿evidencia científica o conocimiento transpuesto?
CPU-e, 2015 El artículo analiza los contenidos conceptuales, procedimentales y valorales de las Normas Oficiales Mexicanas NOM-015-SSA2-2010 “Para la prevención, tratamiento y control de la diabetes mellitus” y NOM-043-SSA2-2012 “Servicios Básicos de Salud ...
Mtro. Juan Manuel Muñoz Cano
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ciência & Educação, 2006 Relata-se o desenvolvimento do sistema hipermídia Anticorpos Monoclonais, com desenho baseado no conhecimento estrutural de um especialista de conteúdo.
Miriam Struchiner +2 more
doaj +1 more source