Results 61 to 70 of about 55,461 (257)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Representación Gráfica: recurso heurístico-didáctico para la enseñanza-aprendizaje de la Matemática (Graphical Representation: a heuristic-didactic resource for the teaching-learning of Mathematics)

Revista Digital Matemática, Educación e Internet
Las limitaciones y dificultades que presentan los estudiantes en el aprendizaje de la Matemática ponen de manifiesto la necesidad de dotar a los docentes de estrategias para favorecer su proceso de enseñanza-aprendizaje.
Sergio Bermudo Navarrete, Abel Cabrera Martínez, Jose Carlos Pinto Leivas, Osvaldo de Jesús Rojas Velázquez, José M. Sigarreta Almira   +4 more
doaj   +1 more source

What makes mass housing representations so different, so appealing?

Cidades, Comunidades e Território, 2022
References to mass housing complexes tend to balance between their generally unknown realities and the pervasive power of their representations. These are often nourished by emotional experiences conveyed by words and images in mass media and political ...
Carlos Machado e Moura
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Biplot AMMI graphic representation of specific combining ability

Crop Breeding and Applied Biotechnology, 2002
Specific combining ability (SCA) is a genetic property of great interest in breeding programs aiming at hybrid cultivars. It enables assessment of the genotype combinations most promising for hybridization.
João Batista Duarte, Rogério de Melo Costa Pinto   +1 more
doaj  

Graphical Representation of Complex Numbers [PDF]

Nature, 1935
A SEARCH of the older texts has revealed an error in the analytical treatment of the graphical representation of complex numbers by Wessel in his original memoir on the subject to the Royal Academy of Denmark in 1797. The error has been perpetuated by many subsequent writers.
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

On Connection between Second-Order Delay Differential Equations and Integrodifferential Equations with Delay

Advances in Difference Equations, 2010
The existence and uniqueness of solutions and a representation of solution formulas are studied for the following initial value problem: ,  ,  , , .
Diblík Josef, Šmarda Zdenĕk, Berezansky Leonid   +2 more
doaj  

Graphical Representations of Consensus Belief

CoRR, 2013
Graphical models based on conditional independence support concise encodings of the subjective belief of a single agent. A natural question is whether the consensus belief of a group of agents can be represented with equal parsimony. We prove, under relatively mild assumptions, that even if everyone agrees on a common graph topology, no method of ...
David M. Pennock, Michael P. Wellman
openaire   +3 more sources