Results 61 to 70 of about 3,718,583 (296)
Existence and multiplicity of solutions for some three-point nonlinear boundary value problems
Journal of Inequalities and Applications, 2006 We study the existence and multiplicity of solutions for the three-point nonlinear boundary value problem , ; , where , , and are assumed to be positive and have some singularities, and is a positive parameter. Under certain conditions, we prove that
O'Regan Donal, Xian Xu
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
On the Kneser problem for two-dimensional differential systems with advanced arguments
Journal of Inequalities and Applications, 2002 For the differential system with advanced arguments , sufficient conditions are established for the existence and uniqueness of a solution of the Kneser problem and the asymptotic behaviour of this solution is studied.
Kiguradze I, Partsvania N
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
, 2021 typo/graphic days is an annual event of lectures and workshops on typography and graphic design organized by the The Semiotics and Visual Communication Lab (SVC Lab) of the Department of Multimedia Lab, the Language and Graphic Communication Research Lab,
Panayides, Angelos
core
July 1970 presentation of Harvey W. Scott books
, 1970 In July 1970, relatives of Harvey W. Scott attend the Harvey W. Scott book presentation. Pictured (left to right) are Elesa Scott Keeney, librarian Lou Flannery, Harvey W. Scott II, Pacific University president Miller A. F.
The Photo Graphic, publisher
core +1 more source
Unbounded Solutions of Second-Order Multipoint Boundary Value Problem on the Half-Line
Boundary Value Problems, 2010 This paper investigates the second-order multipoint boundary value problem on the half-line , , , , , where , , , , and is continuous. We establish sufficient conditions to guarantee the existence of unbounded solution in a special function ...
Wu Yonghong, Liu Lishan, Hao Xinan
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Advances in Difference Equations, 2009 In this paper we study the boundedness, the persistence, the attractivity and the stability of the positive solutions of the nonlinear difference equation , where and .
Schinas CJ +2 more
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source