Results 71 to 80 of about 3,718,583 (296)

The Early Byzantine Domed Basilicas of West Asia Minor, An essay in Graphic Reconstruction [PDF]

open access: yes, 2012
This paper investigates the methodology employed in the recent survey and reconstruction of the major Early Byzantine domed churches of west Asia Minor.
Karydis, Nikolaos
core   +1 more source

An Implicit Hierarchical Fixed-Point Approach to General Variational Inequalities in Hilbert Spaces

open access: yesFixed Point Theory and Applications, 2011
Let be a nonempty closed convex subset of a real Hilbert space . Let be a -Lipschitzian and -strongly monotone operator with constants , be nonexpansive mappings with where denotes the fixed-point set of , and be a -contraction with ...
Wen Ching-Feng, Yao JC, Zeng LC
doaj  

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

An Implicit Extragradient Method for Hierarchical Variational Inequalities

open access: yesFixed Point Theory and Applications, 2011
As a well-known numerical method, the extragradient method solves numerically the variational inequality of finding such that , for all . In this paper, we devote to solve the following hierarchical variational inequality Find such that , for
Liou YeongCheng, Yao Yonghong
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Convergence of Paths for Perturbed Maximal Monotone Mappings in Hilbert Spaces

open access: yesFixed Point Theory and Applications, 2010
Let be a Hilbert space and a nonempty closed convex subset of . Let be a maximal monotone mapping and a bounded demicontinuous strong pseudocontraction. Let be the unique solution to the equation . Then is bounded if and only if converges
Zhou Haiyun   +3 more
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Eigenvalue Problems and Bifurcation of Nonhomogeneous Semilinear Elliptic Equations in Exterior Strip Domains

open access: yesBoundary Value Problems, 2007
We consider the following eigenvalue problems: in in where , , is a smooth bounded domain, , is a smooth bounded domain in such that . Under some suitable conditions on and , we show that there exists a positive constant such that the above ...
Hsu Tsing-San
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Existence of extremal solutions for quadratic fuzzy equations

open access: yesFixed Point Theory and Applications, 2005
Some results on the existence of solution for certain fuzzy equations are revised and extended. In this paper, we establish the existence of a solution for the fuzzy equation , where , , , and are positive fuzzy numbers satisfying certain conditions ...
Nieto Juan J   +1 more
doaj  

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