Results 51 to 60 of about 48,970 (328)
bcrm: Bayesian Continual Reassessment Method Designs for Phase I Dose-Finding Trials
Journal of Statistical Software, 2013 This paper presents the R package bcrm for conducting and assessing Bayesian continual reassessment method (CRM) designs in Phase I dose-escalation trials. CRM designsare a class of adaptive design that select the dose to be given to the next recruited
Michael Sweeting +2 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
The Polyhedral Geometry of Graphical Designs
, 2023 Thesis (Ph.D.)--University of Washington, 2023A graphical design is a quadrature rule for a graph. That is, a graphical design is a subset of graph vertices for which the global averages of certain Laplacian eigenvectors are equal to weighted averages of
Babecki, Catherine
core
MATEC Web of Conferences, 2017 The computation of the information content of decoupled designs implies the use of conditional probability, because the existing design parameters must be adjusted in a certain order, as to fulfil all the existing functional requirements at the first ...
Fradinho João +4 more
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
A New Graphical Method for Pinch Analysis and Energy Integration
Chemical Engineering Transactions, 2015 This research proposes a new graphical method for the analysis of heat recovery systems, applicable to both phases of grassroots and revamping. The new graphical method is based on plotting temperatures of process hot streams versus temperatures of ...
M. Gadalla
doaj +1 more source
Bounding graphical t-wise balanced designs
, 1996 Let X be the edges of the complete graph Kn on n vertices, provided with the natural action of Sn, the automorphism group of Kn. A t-wise balanced design (X, B) with parameters t-((2n), K, λ) is said to be graphical if B is fixed under the action of Sn ...
Chouinard, Leo G.
core +1 more source
MetaCraft: Database-driven metalens design and optimization software
SoftwareXMetalens design and optimization software (MetaCraft) is a Python-based software that generates a variety of metalens designs based on the user preferences.
Jaebum Noh +5 more
doaj +1 more source