Results 81 to 90 of about 48,970 (328)
Accurate Complex Systems Design: Integrating Serious Games with Petri Nets
International Journal of Serious Games, 2016 Difficulty understanding the large number of interactions involved in complex systems makes their successful engineering a problem. Petri Nets are one graphical modelling technique used to describe and check proposed designs of complex systems thoroughly.
Kirsten Sinclair, Daniel Livingstone
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Graphical t-wise balanced designs
, 1983 A pair (X, B) will be a t-wise balanced design (tBD) of type t−(v, K, λ) if B = (Bi: i ϵ I) is a family of subsets of X, called blocks, such that: (i) |X| = v ϵ N, where N is the set of positive integers; (ii) 1⩽t⩽|Bi|ϵK⊆N, for every i ϵ I; and (iii) if ...
Chouinard, L.G. +2 more
core +1 more source
Planning multi-arm screening studies within the context of a drug development programme [PDF]
, 2013 Screening trials are small trials used to decide whether an intervention is sufficiently promising to warrant a large confirmatory trial. Previous literature examined the situation where treatments are tested sequentially until one is considered ...
Wason JMS +9 more
core +1 more source
SoftwareX, 2018 We present AudExpCreator, a GUI-based Matlab tool for designing and creating auditory experiments. AudExpCreator allows users to generate auditory experiments that run on Matlab’s Psychophysics Toolbox without having to write any code; rather, users ...
Duc T. Nguyen, Blair Kaneshiro
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Exploring search behaviour across expertise levels: Graphical vs. form-based interfaces
Information Research: An International Electronic JournalIntroduction. This study explores how graphical and form-based search interfaces influence query reformulation strategies and search performance across two user cohorts: search professionals and master’s students. Method. Using a lab-based user study,
Tony Russell-Rose, Tanja Svarre
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
ASK LDT 2.0: A web-based graphical tool for authoring learning designs
, 2013 During the last decade, Open Educational Resources (OERs) have gained increased attention for their potential to support open access, sharing and reuse of digital educational resources.
Sampson, Demetrios +2 more
core