Results 51 to 60 of about 115,881,303 (256)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The effectiveness of intersection attack countermeasures for graphical passwords [PDF]

, 2012
Recognition-based graphical passwords are one of several proposed alternatives to alphanumerical passwords for user authentication. However, there has been limited work on the security of such schemes.
English, R., Poet, R., Rosanne English, Ron Poet   +3 more
core   +1 more source

Modified XLindley distribution: Properties, estimation, and applications

AIP Advances, 2023
This article aims to introduce the inverse new XLindley distribution, a further extension of the new XLindley distribution. The article explores various properties of the proposed model, such as the quantile function, stochastic orders, entropies, fuzzy ...
Ahmed M. Gemeay, Abdelfateh Beghriche, Laxmi Prasad Sapkota, Halim Zeghdoudi, Nicholas Makumi, M. E. Bakr, Oluwafemi Samson Balogun   +6 more
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Iterative reconstruction of high-dimensional Gaussian Graphical Models based on a new method to estimate partial correlations under constraints. [PDF]

, 2012
In the context of Gaussian Graphical Models (GGMs) with high-dimensional small sample data, we present a simple procedure, called PACOSE - standing for PArtial COrrelation SElection - to estimate partial correlations under the constraint that some of ...
Bender Andreas, Bender, A., Anne-Laure Boulesteix, Boulesteix, Anne-Laure, Andreas Bender, Bender, Andreas, Boulesteix Anne-Laure, Guillemot, Vincent, Vincent Guillemot, Guillemot Vincent   +9 more
core   +1 more source

Computational statistics and biometry: which discipline drives which?

GMS Medizinische Informatik, Biometrie und Epidemiologie, 2005
A biometrician's work is defined through the biological or medical problem and the mathematical and statistical methods needed for its solution. This requires in most instances statistical data analysis and the use of methods of computational statistics.
Edler, Lutz
doaj  

A review of user-friendly freely-available statistical analysis software for medical researchers and biostatisticians

Research in Statistics
Most experimental medical research, if not all of it, heavily relies on statistical analysis. The difficulty of using statistical software is one of the key reasons why many researchers struggle with the data analysis stage.
Laith Ashour
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Is the Bland-Altman plot method useful without inferences for accuracy, precision, and agreement? [PDF]

Revista de Saúde Pública
OBJECTIVE This study aims to propose a comprehensive alternative to the Bland-Altman plot method, addressing its limitations and providing a statistical framework for evaluating the equivalences of measurement techniques.
Paulo Sergio Panse Silveira, Joaquim Edson Vieira, José de Oliveira Siqueira   +2 more
doaj   +1 more source