Results 61 to 70 of about 115,881,303 (256)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Exploratory data analysis of physicochemical parameters of natural antimicrobial and anticancer peptides: Unraveling the patterns and trends for the rational design of novel peptides [PDF]
BioImpactsIntroduction: Peptide-based research has attained new avenues in the antibiotics and cancer drug resistance era. The basis of peptide design research lies in playing with or altering physicochemical parameters. Here in this work, we have done exploratory
Sandeep Saini +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Proceedings of Formal Methods in Computer-Aided Design, FMCAD 2023
, 2023 The Conference on Formal Methods in Computer-Aided Design (FMCAD) is an annual conference on the theory and applications of formal methods in hardware and system in academia and industry for presenting and discussing groundbreaking methods, technologies,
Formal Methods in Computer Aided Design
core +1 more source
Network meta-analysis: application and practice using R software [PDF]
Epidemiology and Health, 2019 The objective of this study is to describe the general approaches to network meta-analysis that are available for quantitative data synthesis using R software.
Sung Ryul Shim +3 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
SUBSIDIZING AGRICULTURAL RISKS: TRENDS AND OPPORTUNITIES [PDF]
Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2016 The paper analyzed the issue of subsidizing agricultural risks in Moldova. The data were collected from the National Bureau of Statistics of the Republic of Moldova, the Agency for Payments and Intervention for Agriculture, National Commission of ...
Maria COJOCARU, Iulia CAPRIAN
doaj
Разработка и регистрация лекарственных средств, 2019 Introduction. «Linearity» is one of the required characteristics when validating analytical procedures. The issues of the validation of linearity procedures are still relevant.Aim.
N. A. Epshtein
doaj +1 more source
Systemic Introduction to Technology Planning in the Context of Technology Competitiveness [PDF]
Journal of Competitiveness, 2013 The concept of a technolog y strateg y (TS) has been developing in the literature of Technology management since the 1970s. TS has been defined as a set of technology and related objectives, variant scenarios, technology roadmaps, targeting practices ...
Jemala Marek
doaj +1 more source