Results 61 to 70 of about 151,101 (262)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Разработка и регистрация лекарственных средств, 2019 Introduction. «Linearity» is one of the required characteristics when validating analytical procedures. The issues of the validation of linearity procedures are still relevant.Aim.
N. A. Epshtein
doaj +1 more source
Systemic Introduction to Technology Planning in the Context of Technology Competitiveness [PDF]
Journal of Competitiveness, 2013 The concept of a technolog y strateg y (TS) has been developing in the literature of Technology management since the 1970s. TS has been defined as a set of technology and related objectives, variant scenarios, technology roadmaps, targeting practices ...
Jemala Marek
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
SUBSIDIZING AGRICULTURAL RISKS: TRENDS AND OPPORTUNITIES [PDF]
Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2016 The paper analyzed the issue of subsidizing agricultural risks in Moldova. The data were collected from the National Bureau of Statistics of the Republic of Moldova, the Agency for Payments and Intervention for Agriculture, National Commission of ...
Maria COJOCARU, Iulia CAPRIAN
doaj
New Graphical Methods and Test Statistics for Testing Composite Normality [PDF]
Econometrics, 2015 Several graphical methods for testing univariate composite normality from an i.i.d. sample are presented. They are endowed with correct simultaneous error bounds and yield size-correct tests. As all are based on the empirical CDF, they are also consistent for all alternatives.
openaire +3 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Cluster variation method in statistical physics and probabilistic graphical models [PDF]
Journal of Physics A: Mathematical and General, 2005 36 pages, 17 ...
openaire +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source