Results 161 to 170 of about 22,175,501 (301)

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Enhancing healthcare analytics with prompt based probabilistic graphical model. [PDF]

iScience
Zhuang Y, Zhang J, Liu S, Wei B, Zheng L, Gao J, Zeng Z, Xu J, He K.   +8 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Network construction using sparse Gaussian graphical model based on GWAS summary statistics. [PDF]

Sci Rep
Subedi M, Cao X, Kim BJ, Sha Q.
europepmc   +1 more source

An Integrated Approach of Learning Genetic Networks From Genome-Wide Gene Expression Data Using Gaussian Graphical Model and Monte Carlo Method. [PDF]

Bioinform Biol Insights, 2023
Zhao H, Datta S, Duan ZH.
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Modeling Alzheimer's disease: Bayesian copula graphical model from demographic, cognitive, and neuroimaging data. [PDF]

J Alzheimers Dis
Vogels L, Mohammadi R, Schoonhoven M, Birbil ŞI, Dyrba M, Alzheimer’s Disease Neuroimaging Initiative.   +5 more
europepmc   +1 more source

BAGEL: A BAYESIAN GRAPHICAL MODEL FOR INFERRING DRUG EFFECT LONGITUDINALLY ON DEPRESSION IN PEOPLE WITH HIV. [PDF]

Ann Appl Stat, 2022
Li Y, Ni Y, Rubin LH, Spence AB, Xu Y.
europepmc   +1 more source

Non-uniqueness of phase transitions for graphical representations of the Ising model on tree-like graphs

Ulrik Thinggaard Hansen, Frederik Ravn Klausen, Peter Wildemann   +2 more
openalex   +1 more source

A Probabilistic Graphical Model Foundation for Enabling Predictive\n Digital Twins at Scale [PDF]

, 2020
Michael G. Kapteyn, Jacob V. R. Pretorius, Karen Willcox   +2 more
openalex   +1 more source