Results 161 to 170 of about 22,057,993 (342)

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

open access: yesFEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu   +9 more
wiley   +1 more source

Meta graphical lasso: uncovering hidden interactions among latent mechanisms

open access: yesScientific Reports
In complex systems, it’s crucial to uncover latent mechanisms and their context-dependent relationships. This is especially true in medical research, where identifying unknown cancer mechanisms and their impact on phenomena like drug resistance is vital.
Koji Maruhashi   +3 more
doaj   +1 more source

Semi‐automated hippocampal avoidance whole‐brain radiotherapy planning

open access: yesJournal of Applied Clinical Medical Physics, Volume 26, Issue 7, July 2025.
Abstract Background Hippocampal avoidance whole‐brain radiotherapy (HA‐WBRT) is designed to spare cognitive function by reducing radiation dose to the hippocampus during the treatment of brain metastases. Current manual planning methods can be time‐consuming and may vary in quality, necessitating the development of automated approaches to streamline ...
Dong Joo Rhee   +9 more
wiley   +1 more source

High-Dimensional Graphical Model Search with the gRapHD R Package

open access: yesJournal of Statistical Software, 2010
This paper presents the R package gRapHD for efficient selection of high-dimensional undirected graphical models. The package provides tools for selecting trees, forests, and decomposable models minimizing information criteria such as AIC or BIC, and for
Gabriel C. G. Abreu   +2 more
doaj  

Enhanced analysis of gating latency in 0.35T MR‐linac through innovative time synchronization of a motion phantom and plastic scintillation detector

open access: yesJournal of Applied Clinical Medical Physics, Volume 26, Issue 7, July 2025.
Abstract Purpose This study aims to evaluate how different gantry angles, breathing rates (BPM), cine image speeds, and tracking algorithms affect beam on/off latency and the subsequent impact on target dose for a 0.35T MR‐Linac with a 6 MV FFF beam.
Mateb Al Khalifa   +4 more
wiley   +1 more source

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