Results 71 to 80 of about 1,244,068 (326)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Discussion: Latent variable graphical model selection via convex optimization

open access: yes, 2012
Discussion of "Latent variable graphical model selection via convex optimization" by Venkat Chandrasekaran, Pablo A. Parrilo and Alan S. Willsky [arXiv:1008.1290].Comment: Published in at http://dx.doi.org/10.1214/12-AOS981 the Annals of Statistics ...
Wainwright, Martin J.
core   +1 more source

Graphical Independence Networks with the gRain Package for R

open access: yesJournal of Statistical Software, 2012
In this paper we present the R package gRain for propagation in graphical independence networks (for which Bayesian networks is a special instance). The paper includes a description of the theory behind the computations.
Soren Hojsgaard
doaj  

Structure Learning in Graphical Modeling [PDF]

open access: yesAnnual Review of Statistics and Its Application, 2017
A graphical model is a statistical model that is associated with a graph whose nodes correspond to variables of interest. The edges of the graph reflect allowed conditional dependencies among the variables. Graphical models have computationally convenient factorization properties and have long been a valuable tool for tractable modeling of multivariate
Drton M., Maathuis M.H.
openaire   +3 more sources

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

Loop Calculus for Non-Binary Alphabets using Concepts from Information Geometry [PDF]

open access: yes, 2014
The Bethe approximation is a well-known approximation of the partition function used in statistical physics. Recently, an equality relating the partition function and its Bethe approximation was obtained for graphical models with binary variables by ...
Mori, Ryuhei
core   +1 more source

Bayesian Network Modeling Applied to Feline Calicivirus Infection Among Cats in Switzerland

open access: yesFrontiers in Veterinary Science, 2020
Bayesian network (BN) modeling is a rich and flexible analytical framework capable of elucidating complex veterinary epidemiological data. It is a graphical modeling technique that enables the visual presentation of multi-dimensional results while ...
Gilles Kratzer   +11 more
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Learning the Structure of Hub Network Based on Graph Model

open access: yesXibei Gongye Daxue Xuebao, 2019
In this paper, we focus on the structure learning problem of the hub network. In the neighborhood selection framework, we use the L1 and L2 regularizers to incorporate the sparse and group prior of the hub network, so as to make the network easier to ...

doaj   +1 more source

Topological Modeling for Vector Graphics [PDF]

open access: yesIEEE Computer Graphics and Applications, 2019
In recent years, with the development of mobile phones, tablets, and web technologies, we have seen an ever-increasing need to generate vector graphics content, that is, resolution-independent images that support sharp rendering across all devices, as well as interactivity and animation.
James D. Foley, Boris Dalstein
openaire   +3 more sources

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