Results 91 to 100 of about 418,262 (313)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Graphical model used for the simulations.

open access: yes, 2016
The graphical model is a Dynamic Bayesian Network [62] and expresses the probabilistic relations between variables. See the main text for explanation.
Domenico Maisto (3174690)   +2 more
core   +1 more source

nference in Graphical Gaussian Models with Edge and Vertex Symmetries with the gRc Package for R

open access: yesJournal of Statistical Software, 2007
In this paper we present the R package gRc for statistical inference in graphical Gaussian models in which symmetry restrictions have been imposed on the concentration or partial correlation matrix.
Søren Højsgaard, Steffen L. Lauritzen
doaj  

Graphical models of separation logic

open access: yesInformation Processing Letters, 2009
Labelled graphs are used to model control and data flow among events occurring in the execution of a (possibly concurrent) program. Data flow is a unifying concept that covers both access to memory and communication along channels; it covers many variations including weakly consistent memory, re-ordered execution, and communication channels that are ...
Wehrman, I, Hoare, C, O'Hearn, P
openaire   +2 more sources

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Functional graphical model classification

open access: yes, 2019
The functional magnetic resonance imaging (fMRI) records signals coming from human brains, which show activities and states of brains. This measurements result in a high-dimensional time series, and each dimension represents a region of brains.
Li, P., Maiti, T.
core   +1 more source

Spatio-Temporal Graphical-Model-Based Multiple Facial Feature Tracking

open access: yesEURASIP Journal on Advances in Signal Processing, 2005
It is challenging to track multiple facial features simultaneously when rich expressions are presented on a face. We propose a two-step solution. In the first step, several independent condensation-style particle filters are utilized to track each ...
Su Congyong, Huang Li
doaj   +1 more source

Probabilistic Graphical Models [PDF]

open access: yes, 2014
This report presents probabilistic graphical models that are based on imprecise probabilities using a simplified language. In particular the discussion is focused on credal networks and discrete domains. It describes the building blocks of credal networks algorithms to perform inference and discusses on complexity results and related work.
Antonucci, Alessandro   +2 more
openaire   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

A Graphical Model for Protein Secondary Structure Prediction [PDF]

open access: yes, 2004
In this paper, we present a graphical model for protein secondary structure ...
David L. Wild   +3 more
core   +1 more source

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