Results 51 to 60 of about 1,036,354 (257)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

FACE: Feature-preserving CAD model surface reconstruction

Graphical Models
Feature lines play a pivotal role in the reconstruction of CAD models. Currently, there is a lack of a robust explicit reconstruction algorithm capable of achieving sharp feature reconstruction in point clouds with noise and non-uniformity. In this paper,
Shuxian Cai, Yuanyan Ye, Juan Cao, Zhonggui Chen   +3 more
doaj   +1 more source

Context-specific independencies for ordinal variables in chain regression models [PDF]

, 2017
In this work we handle with categorical (ordinal) variables and we focus on the (in)dependence relationship under the marginal, conditional and context-specific perspective.
Cazzaro, Manuela, Nicolussi, Federica
core   +1 more source

Lattices of Graphical Gaussian Models with Symmetries

, 2011
In order to make graphical Gaussian models a viable modelling tool when the number of variables outgrows the number of observations, model classes which place equality restrictions on concentrations or partial correlations have previously been introduced
Andersen, Anderson, Bollobás, Brown, Buhl, Complet, Dobiński, Edwards, Grätzer, Helene Gehrmann, Lauritzen, Mardia, Olkin, Sachs, Schmidt, Whittaker   +15 more
core   +3 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Sketch-2-4D: Sketch driven dynamic 3D scene generation

Graphical Models
Sketch-based content generation offers flexible controllability, making it a promising narrative avenue in film production. Directors often visualize their imagination by crafting storyboards using sketches and textual descriptions for each shot. However,
Guo-Wei Yang, Dong-Yu Chen, Tai-Jiang Mu
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Exploring the neural landscape: Visual analytics of neuron activation in large language models with NeuronautLLM

Graphical Models
Large language models (LLMs) like those that power OpenAI’s ChatGPT and Google’s Gemini have played a major part in the recent wave of machine learning and artificial intelligence advancements.
Ollie Woodman, Zhen Wen, Hui Lu, Yiwen Ren, Minfeng Zhu, Wei Chen   +5 more
doaj   +1 more source

Duality in Graphical Models [PDF]

, 2013
Graphical models have proven to be powerful tools for representing high-dimensional systems of random variables. One example of such a model is the undirected graph, in which lack of an edge represents conditional independence between two random ...
Malouche, Dhafer, Rajaratnam, Bala, Rolfs, Benjamin T.   +2 more
core  

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source