Results 61 to 70 of about 317,964 (264)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Graphical models of separation logic

Information Processing Letters, 2009
Labelled graphs are used to model control and data flow among events occurring in the execution of a (possibly concurrent) program. Data flow is a unifying concept that covers both access to memory and communication along channels; it covers many variations including weakly consistent memory, re-ordered execution, and communication channels that are ...
Wehrman, I, Hoare, C, O'Hearn, P
openaire   +2 more sources

Improving the area-preserving parameterization of rational Bézier surfaces by rational bilinear transformation

Graphical Models
To improve the area-preserving parameterization quality of rational Bézier surfaces, an optimization algorithm using bilinear reparameterization is proposed.
Xiaowei Li, Yingjie Wu, Yaohui Sun, Xin Chen, Yanru Chen, Yi-jun Yang   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

DISCO: Efficient Diffusion Solver for large-scale Combinatorial Optimization problems

Graphical Models
Combinatorial Optimization (CO) problems are fundamentally important in numerous real-world applications across diverse industries, notably computer graphics, characterized by entailing enormous solution space and demanding time-sensitive response ...
Hang Zhao, Kexiong Yu, Yuhang Huang, Renjiao Yi, Chenyang Zhu, Kai Xu   +5 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Graphical models for graph matching

Proceedings of the 2004 IEEE Computer Society Conference on Computer Vision and Pattern Recognition, 2004. CVPR 2004., 2004
Technical report TR03-21. This paper explores a formulation for attributed graph matching as an inference problem over a hidden Markov Random Field. We approximate the fully connected model with simpler models in which optimal inference is feasible, and contrast them to the well-known probabilistic relaxation method, which can operate over the complete
Caelli, Terry, Caetano, Tiberio, Barone, Dante   +2 more
openaire   +3 more sources

Efficient RANSAC in 4D Plane Space for Point Cloud Registration

Graphical Models
3D registration methods based on point-level information struggle in situations with noise, density variation, large-scale points, and small overlaps, while existing primitive-based methods are usually sensitive to tiny errors in the primitive extraction
Chang Liu, Chao Liu, Yuming Zhang, Zhongqi Wu, Jianwei Guo   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Visual simulation of fruit chilling injury

Graphical Models
Chilling injury (CI) is a major postharvest physiological disorder in fruits, causing quality degradation and economic losses during low-temperature storage.
Yixin Xu, Shiguang Liu
doaj   +1 more source