Results 1 to 10 of about 1,246,664 (382)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Architecture of the Graphics System for Embedded Real-Time Operating Systems [PDF]
, 2022 А.М. Гиацинтов +2 more
openalex +1 more source
Realtime 3D graphics programming using the Quake3 engine [PDF]
, 2008 We present a lab assignment that accompanies a complete module called Real-time Graphics . The students task is to get familiar with content creation and programming a (previously) commercial 3D engine.
Kainz, B, Schmalstieg, D, Wagner, D
core
Journal of the Scientific Society, 2023 Rajendra B Nerli, Shridhar C Ghagane
openaire +2 more sources
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
SkillSum: basic skills screening with personalised, computer-generated feedback [PDF]
, 2008 We report on our experiences in developing and evaluating a system that provided formative assessment of basic skills and automatically generated personalised feedback reports for 16-19 year-old users.
Reiter, Ehud, Williams, Sandra
core +3 more sources
Statistical Science, 2004 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +3 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Methodological Foundations for Teaching Computer Graphics for Students in IT Areas
, 2020 Vitaly Vladislavovich Karabchevsky
openalex +1 more source