Results 131 to 140 of about 303,097 (314)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Distinctive Approaches to Computer Graphics Education
, 2017 This paper presents the latest advances and research in Computer Graphics education in a nutshell. It is concerned with topics that were presented at the Education Track of the Eurographics Conference held in Lisbon in 2016.
Ferko, A. +38 more
core +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Automated testing of computer graphics systems
, 2022 S.L1-L11 : Abb.,Lit.Graphics Systems have become increasingly complex over the last years. Computer Graphics standards provide the means to implement portable graphics applications.
Goebel, M., Jorge, J., Ziegler, R.
core
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Искусство ЕвразииСтатья посвящена ранним живописным и графическим произведениям одного из самых «левых» художников омского авангарда 1910-х – начала 1920-х годов Виктора Ивановича Уфимцева.
Богомолова, Л.К.
doaj +1 more source
THE ANALISYS OF NARRATIVE AND SYMBOLIC STRUCTURES IN BOOK GRAPHICS IN THE MOLDOVAN SOVIET SOCIALIST REPUBLIC IN THE PERIOD OF SOCIALIST REALISM (1945-1953) [PDF]
Studiul Artelor şi Culturologie: Istorie, Teorie, Practică, 2016 In the process of transition to socialist realism, the fine art of the ‘40s, including graphics, was characterized by documentalism and illustrativism in various thematic approaches to everyday life.
ROCACIUC VICTORIA
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source