Results 31 to 40 of about 32,874 (261)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

GENETIC ALGORITHM ON GENERAL PURPOSE GRAPHICS PROCESSING UNIT: PARALLELISM REVIEW [PDF]

ICTACT Journal on Soft Computing, 2013
Genetic Algorithm (GA) is effective and robust method for solving many optimization problems. However, it may take more runs (iterations) and time to get optimal solution.
A.J. Umbarkar, M.S. Joshi, N.M. Rothe
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

eccCL: parallelized GPU implementation of Ensemble Classifier Chains

BMC Bioinformatics, 2017
Background Multi-label classification has recently gained great attention in diverse fields of research, e.g., in biomedical application such as protein function prediction or drug resistance testing in HIV.
Mona Riemenschneider, Alexander Herbst, Ari Rasch, Sergei Gorlatch, Dominik Heider   +4 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Method of computing on graphics processors

Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019
An overview of a simple and efficient method to abort execution of a running kernel on graphics processing unit when it is required for fast release of its resources is presented.
I. N. Hubchyk, N. N. Ivanov
doaj  

PyGAMD: Python graphics processing unit‐accelerated molecular dynamics software

Materials Genome Engineering Advances
PyGAMD (Python GPU‐accelerated molecular dynamics software) is a molecular simulation platform developed from scratch. It is designed for soft matter, especially for polymer by integrating coarse‐grained/multi‐scale models, methods, and force fields.
Jialei Xu, Shenghong Guo, Miaolan Zhen, Zhuochen Yu, Youliang Zhu, Giuseppe Milano, Zhongyuan Lu   +6 more
doaj   +1 more source

Efficient channelization on a graphics processing unit

Journal of Astronomical Telescopes, Instruments, and Systems, 2023
We present an implementation of a channelizer (F-engine) running on a Graphics Processing Unit (GPU). While not the first GPU implementation of a channelizer, we have put significant effort into optimizing the implementation. We are able to process four antennas each with 2 Gsample/s, 10-bit dual-polarized input and 8-bit output, on a single commodity ...
openaire   +2 more sources