Results 71 to 80 of about 233,815 (328)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
BMC Research Notes, 2009 Background The Smith-Waterman algorithm is one of the most widely used tools for searching biological sequence databases due to its high sensitivity. Unfortunately, the Smith-Waterman algorithm is computationally demanding, which is further compounded by
Maskell Douglas L +2 more
doaj +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Accelarated Optical Character Recognition on Graphics Processing Units
International Journal of Information and Communication Technology Research, 2013 Optical Character Recognition (OCR) is a technique by the help of which the optical characters are identified automatically by a computer. There are many methods for OCR, one of which is neural network that we use.
Ehsan Arianyan +3 more
doaj
Graphics Processing Unit: An Introduction
, 2019 Graphics Processing Unit GPU is a processor or electronic chip for graphics. GPUs are massively parallel processors used widely used for 3D graphic and many non graphic applications. As the demand for graphics applications increases, GPU has become indispensable.
Sadiku, Matthew N. O. +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
IEEE AccessSubgraph matching is a key graph analysis technique employed in a wide range of fields, including security threat detection and biological network analysis.
Jongwoo Jeon +5 more
doaj +1 more source
IEEE Access, 2019 The power consumption models of mobile application processors have emerged as key objects of interest following the tremendous growth in mobile device production given that such consumption is an important factor in the graphics performance of mobile ...
Juwon Yun +6 more
doaj +1 more source
Real-time digital holographic microscopy observable in multi-view and multi-resolution
, 2010 We propose a real-time digital holographic microscopy, that enables simultaneous multiple reconstructed images with arbitrary resolution, depth and positions, using Shifted-Fresnel diffraction instead of Fresnel diffraction.
Ichihashi, Yasuyuki +3 more
core +1 more source