Results 111 to 120 of about 3,309,871 (369)

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

A Heuristic Process for GUI Widget Matching Across Application Versions [PDF]

Annales Universitatis Scientiarum Budapest, Sectio Computatorica Vol 36, pages 255 - 275 (2012), 2017
This paper introduces an automated heuristic process able to achieve high accuracy when matching graphical user interface widgets across multiple versions of a target application. The proposed implementation is flexible as it allows full customization of the process and easy integration with existing tools for long term graphical user interface test ...
arxiv  

Onboard shuttle on-line software requirements system: Prototype [PDF]

The prototype discussed here was developed as proof of a concept for a system which could support high volumes of requirements documents with integrated text and graphics; the solution proposed here could be extended to other projects whose goal is to ...
Kolkhorst, Barbara, Ogletree, Barry
core   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

PC graphics generation and management tool for real-time applications [PDF]

A graphics tool was designed and developed for easy generation and management of personal computer graphics. It also provides methods and 'run-time' software for many common artificial intelligence (AI) or expert system (ES ...
Truong, Long V.
core   +1 more source

A Network Compatible Display Protocol [PDF]

, 1979
At present IIASA offers to its scientific community a set of basic, but limited computer graphics capabilities. Recent computer-program development in the graphics area has created greater demand and more awareness of the possibilities of computer ...
Schweeger, B.
core  

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Prediction of rate of improvement of software quality and development effort on the basis of Degreeof excellence with respect to number of lines of code [PDF]

arXiv, 2014
The objective of this research work is to improve the degree of excellence by removing the number of exceptions from the software. The modern age is more concerned with the quality of software. Extensive research is being carried out in this direction. The rate of improvement of quality of software largely depends on the development time.
arxiv  

Current and future graphics requirements for LaRC and proposed future graphics system [PDF]

The findings of an investigation to assess the current and future graphics requirements of the LaRC researchers with respect to both hardware and software are presented.
Bowen, J. T., Gates, R. L., Randall, D. P., Taylor, N. L.   +3 more
core   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source