Results 41 to 50 of about 638 (208)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Egyptian Grave Goods of Kha and Merit Studied by Neutron and Gamma Techniques [PDF]

Angewandte Chemie International Edition, 2018
AbstractArtifacts from the Egyptian grave goods of Kha and Merit preserved at the Museo Egizio in Turin were studied through a combination of non‐destructive and non‐invasive neutron and gamma techniques (namely neutron imaging, neutron diffraction and prompt gamma activation analysis). The results provide unprecedented morphological reconstructions of
G. Festa, T. Minniti, L. Arcidiacono, M. Borla(d), D. Di Martino, F. Facchetti, E. Ferraris, V. Turina, W. Kockelmann, J. Kelleher, R. Senesi, C. Greco, C. Andreani   +12 more
openaire   +3 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

On the edge of the eurasian steppes: the sarmatian culture in the 1st–3rd centuries ad east of the Carpathians

Поволжская археология
The paper analyses the Sarmatian culture east of the Carpathians during the 1st-3rd centuries AD, shedding light on their burial practices, artefacts, and socio-economic interactions.
Grumeza Lavinia, Cojocaru Victor
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

The evolution burial practice among the Ertebølle

Groundings, 2010
Archaeology has traditionally failed to identify the ability of individuals in the past to make conscious decisions and act creatively. Individuals with the power to act are referred to as agents, with the ability and creativity to make decisions and act
Coralie Acheson
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

The early settlement of Sarmatians in Wallachia / Situri sarmatice timpurii în Muntenia

Tyragetia, 2016
This study aims to analyse the finds that can be connected to what we defined as being the first stage of Sarmatian diffusion in Wallachia. The purpose is not to insist on the date of the arrival, which was debated on several occasions, for it would mean
Liana Oţa, Valeriu Sîrbu
doaj  

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

A Terracotta Treasure at Assos

Les Carnets de l’ACoSt, 2015
During the summer of 1995, Turkish archaeologists discovered a unique Late Classical tomb in the Western Necropolis of Assos. A modestly designed cist grave, Tomb 4 surprised excavators with the richest cache of grave goods ever found at the ancient city.
Tuna Şare Ağtürk, Nurettin Arslan
doaj   +1 more source