Results 41 to 50 of about 5,470,060 (264)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Hypothyroid Graves’ Ophthalmopathy: Report of Two Cases

Endocrinology Research and Practice, 2007
Graves’ disease is an autoimmune disorder of the thyroid gland. Ophthalmopathy is the most common peripheral manifestation of Graves’ disease. It is a very rare condition that a Graves’ patient presents with spontaneous hypothyroidism.
Barış Akıncı, Tevfik Demir, Abdurrahman Çömlekçi   +2 more
doaj   +2 more sources

Graves’ Disease: Introduction

, 2023
Abstract Graves’ disease is a multisystem disorder and the most common autoimmune disease. Fifty percent of patients with Graves’ disease shows orbital involvement, called Graves’ orbitopathy. Although Graves’ orbitopathy is a self-limiting disease, spontaneous improvement can only be awaited in its milder forms.
openaire   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Steroid Treatment Focused Management of Graves’ Ophthalmopathy

Acta Medica Bulgarica
Graves' disease (GD) is an autoimmune disease that affects the thyroid and the eyes. Graves' ophthalmopathy (GO), an autoimmune disease, usually appears 18 months after GD diagnosis.
Condeng Y. H., Umar H., Aman A. M., Rasyid H., Bakri S., Iskandar H.   +5 more
doaj   +1 more source

Predicting remission of Graves' disease following treatment with antithyroid drugs

Клинический разбор в общей медицине, 2023
Graves' disease (GD) is among the most prevalent organ-specific diseases and is one of the most common causes of hyperthyroidism in regions with normal iodine supply.
Natalya V. Drogashevskaya, Ekaterina A. Zhilina, Narine S. Martirosyan, Ekaterina V. Goncharova, Irina A. Kuzina, Nina A. Petunina   +5 more
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Candidate gene associations reveal sex‐specific Graves’ disease risk alleles among Chinese Han populations

Molecular Genetics & Genomic Medicine, 2020
Background With several susceptibility single nucleotide polymorphisms identified by case–control association studies, Graves’ disease is one of the most common forms of autoimmune thyroid disease.
Chen‐Yan Yan, Yu‐Ru Ma, Feng Sun, Rui‐Jia Zhang, Ya Fang, Qian‐Yue Zhang, Feng‐Yao Wu, Shuang‐Xia Zhao, Huai‐Dong Song   +8 more
doaj   +1 more source

Serum selenium status in Graves' disease and Hashimoto's thyroiditis in an iodine-sufficient area: A case–control study

Journal of Research in Medical Sciences, 2022
Background: Selenium (Se) can be found in the molecular structure of selenoproteins; including thioredoxin reductase and glutathione peroxidase and also in Type I and II deiodinases.
Zahra Heidari, Vahid Sheikhi
doaj   +1 more source