Results 91 to 100 of about 747,971 (341)

Extensive Gray Matter Volume Reduction in Treatment-Resistant Schizophrenia [PDF]

International Journal of Neuropsychopharmacology, 2015
Approximately one-third of people with schizophrenia are treatment-resistant and some do not achieve remission with clozapine, the gold-standard antipsychotic medication for treatment-resistant schizophrenia. This study compared global and regional brain volumes between treatment-respondent and treatment-resistant patients with schizophrenia, including
Anderson, Valerie M, Goldstein, Meghan E, Kydd, Robert R., Russell, Bruce R   +3 more
openaire   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A Metabolic Obesity Profile Is Associated With Decreased Gray Matter Volume in Cognitively Healthy Older Adults

Frontiers in Aging Neuroscience, 2019
Obesity is a risk factor for cognitive decline and gray matter volume loss in aging. Studies have shown that different metabolic factors, e.g., dysregulated glucose metabolism and systemic inflammation, might mediate this association.
Frauke Beyer, Frauke Beyer, Shahrzad Kharabian Masouleh, Shahrzad Kharabian Masouleh, Jürgen Kratzsch, Matthias L. Schroeter, Matthias L. Schroeter, Susanne Röhr, Steffi G. Riedel-Heller, Arno Villringer, Arno Villringer, Arno Villringer, A. Veronica Witte, A. Veronica Witte, A. Veronica Witte   +14 more
doaj   +1 more source

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source

Neuroanatomical differences between first-episode psychosis patients with and without neurocognitive deficit: a 3-year longitudinal study [PDF]

, 2016
This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY).[Background]: The course of cognitive function in first-episode psychosis (FEP) patients suggests that some individuals are normal or near ...
Ayesa Arriola, Rosa, Crespo-Facorro, Benedicto, Ferro, Adele, Pérez-Iglesias, Rocío, Roiz-Santiáñez, Roberto, Sainz, Jesús   +5 more
core   +1 more source

White matter lesions and brain gray matter volume in cognitively normal elders [PDF]

Neurobiology of Aging, 2012
Cerebral white matter lesions (WMLs) reflect small vessel disease, are common in elderly individuals, and are associated with cognitive impairment. We sought to determine the relationships between WMLs, age, gray matter (GM) volume, and cognition in the Cardiovascular Health Study (CHS).
Cyrus A, Raji, Oscar L, Lopez, Lewis H, Kuller, Owen T, Carmichael, William T, Longstreth, H Michael, Gach, John, Boardman, Charles B, Bernick, Paul M, Thompson, James T, Becker   +9 more
openaire   +2 more sources

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes. [PDF]

, 2018
Blood-based bioenergetic profiling has promising applications as a minimally invasive biomarker of systemic bioenergetic capacity. In the present study, we examined peripheral blood mononuclear cell (PBMC) mitochondrial function and brain morphology in a
Freedman, Barry I, Hughes, Timothy M, Mahapatra, Gargi, Maldjian, Joseph A, Molina, Anthony JA, Smith, S Carrie, Wagner, Benjamin   +6 more
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