Results 71 to 80 of about 130,672 (260)

White-matter microstructure and gray-matter volumes in adolescents with subthreshold bipolar symptoms [PDF]

Molecular Psychiatry, 2013
Abnormalities in white-matter (WM) microstructure, as lower fractional anisotropy (FA), have been reported in adolescent-onset bipolar disorder and in youth at familial risk for bipolarity. We sought to determine whether healthy adolescents with subthreshold bipolar symptoms (SBP) would have early WM microstructural alterations and whether those ...
Paillère Martinot, M-L, Lemaitre, H, Artiges, E, Miranda, R, Goodman, R, Penttilä, J, Struve, M, Fadai, T, Kappel, V, Poustka, L, Conrod, P, Banaschewski, T, Barbot, A, Barker, G J, Büchel, C, Flor, H, Gallinat, J, Garavan, H, Heinz, A, Ittermann, B, Lawrence, C, Loth, E, Mann, K, Paus, T, Pausova, Z, Rietschel, M, Robbins, T W, Smolka, M N, Schumann, G, Martinot, J-L   +29 more
openaire   +5 more sources

Coping with Childbirth: Brain Structural Associations of Personal Growth Initiative

Frontiers in Psychology, 2017
Major life events require psychological adaptations and can be accompanied by brain structural and functional changes. The goal of the current study was to investigate the association of personal growth initiative (PGI) as a form of proactive coping ...
Judith Mangelsdorf, Judith Mangelsdorf
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

White matter lesions and brain gray matter volume in cognitively normal elders [PDF]

Neurobiology of Aging, 2012
Cerebral white matter lesions (WMLs) reflect small vessel disease, are common in elderly individuals, and are associated with cognitive impairment. We sought to determine the relationships between WMLs, age, gray matter (GM) volume, and cognition in the Cardiovascular Health Study (CHS).
Cyrus A, Raji, Oscar L, Lopez, Lewis H, Kuller, Owen T, Carmichael, William T, Longstreth, H Michael, Gach, John, Boardman, Charles B, Bernick, Paul M, Thompson, James T, Becker   +9 more
openaire   +2 more sources

Cortical Damage Associated With Cognitive and Motor Impairment in Hereditary Spastic Paraplegia: Evidence of a Novel SPAST Mutation

Frontiers in Neurology, 2020
To determine the cortical mechanism that underlies the cognitive impairment and motor disability in hereditary spastic paraplegia (HSP), nine HSP patients from a Chinese family were examined using clinical evaluation, cognitive screening, and genetic ...
Jian-zhong Lin, Hong-hua Zheng, Qi-lin Ma, Chen Wang, Li-ping Fan, Han-ming Wu, Dan-ni Wang, Jia-xing Zhang, Yi-hong Zhan   +8 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Increased cerebellar gray matter volume in head chefs

PLOS ONE, 2017
Chefs exert expert motor and cognitive performances on a daily basis. Neuroimaging has clearly shown that that long-term skill learning (i.e., athletes, musicians, chess player or sommeliers) induces plastic changes in the brain thus enabling tasks to be performed faster and more accurately.
Antonio Cerasa, Alessia Sarica, Iolanda Martino, Carmelo Fabbricatore, Francesco Tomaiuolo, Federico Rocca, Manuela Caracciolo, Aldo Quattrone   +7 more
openaire   +4 more sources

A Metabolic Obesity Profile Is Associated With Decreased Gray Matter Volume in Cognitively Healthy Older Adults

Frontiers in Aging Neuroscience, 2019
Obesity is a risk factor for cognitive decline and gray matter volume loss in aging. Studies have shown that different metabolic factors, e.g., dysregulated glucose metabolism and systemic inflammation, might mediate this association.
Frauke Beyer, Frauke Beyer, Shahrzad Kharabian Masouleh, Shahrzad Kharabian Masouleh, Jürgen Kratzsch, Matthias L. Schroeter, Matthias L. Schroeter, Susanne Röhr, Steffi G. Riedel-Heller, Arno Villringer, Arno Villringer, Arno Villringer, A. Veronica Witte, A. Veronica Witte, A. Veronica Witte   +14 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source