Results 61 to 70 of about 10,411,269 (304)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Increased cerebellar gray matter volume in head chefs

PLOS ONE, 2017
Chefs exert expert motor and cognitive performances on a daily basis. Neuroimaging has clearly shown that that long-term skill learning (i.e., athletes, musicians, chess player or sommeliers) induces plastic changes in the brain thus enabling tasks to be performed faster and more accurately.
Antonio Cerasa, Alessia Sarica, Iolanda Martino, Carmelo Fabbricatore, Francesco Tomaiuolo, Federico Rocca, Manuela Caracciolo, Aldo Quattrone   +7 more
openaire   +4 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Reduced gray matter in the prefrontal cortex and hippocampus: a potential neuroanatomical feature of insomnia comorbid with anxiety

Frontiers in Psychiatry
BackgroundChronic insomnia disorder (CID) frequently comorbid with generalized anxiety disorder (GAD), and accurate identification of this comorbidity remains challenging.
Minghe Xu, Yanjie Zhou, Bei Feng, Kunlin Ni, Xinyu Li, Pan He, Qingzhu Zhao, Yu Fan, Li Xiao, Bing Yu   +9 more
doaj   +1 more source

Alterations of brain gray matter volume in children with obstructive sleep apnea

Frontiers in Neurology, 2023
ObjectiveObstructive sleep apnea (OSA) seriously affects the children's cognitive functions, but the neuroimaging mechanism of cognitive impairment is still unclear. The purpose of our study was to explore the difference in brain local gray matter volume
Chenyi Yu, Yuchuan Fu, Yi Lu, Yinyin Huang, Fangfang Chen, Jiayun Wei, Lingling Li, Janet Akoto Ampadu, Yu Wang, Weikun Zheng, Changcan Jiang, Weiyuan Li, Su Lui, Su Lui, Xiaohong Cai   +14 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Similarity-Based Extraction of Individual Networks from Gray Matter [PDF]

, 2011
The characterization of gray matter morphology of individual brains is an important issue in neuroscience. Graph theory has been used to describe cortical morphology, with networks based on co-variation of gray matter volume or thickness between cortical
S. M. Lawrie, David J. Willshaw, Tijms, Betty Marije, Stephen M. Lawrie, Willshaw, D.J., B. M. Tijms, Lawrie, S.M., P. Series, Tijms, B.M., Series, P., Betty M. Tijms, D. J. Willshaw   +11 more
core   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

White-matter microstructure and gray-matter volumes in adolescents with subthreshold bipolar symptoms [PDF]

Molecular Psychiatry, 2013
Abnormalities in white-matter (WM) microstructure, as lower fractional anisotropy (FA), have been reported in adolescent-onset bipolar disorder and in youth at familial risk for bipolarity. We sought to determine whether healthy adolescents with subthreshold bipolar symptoms (SBP) would have early WM microstructural alterations and whether those ...
Paillère Martinot, M-L, Lemaitre, H, Artiges, E, Miranda, R, Goodman, R, Penttilä, J, Struve, M, Fadai, T, Kappel, V, Poustka, L, Conrod, P, Banaschewski, T, Barbot, A, Barker, G J, Büchel, C, Flor, H, Gallinat, J, Garavan, H, Heinz, A, Ittermann, B, Lawrence, C, Loth, E, Mann, K, Paus, T, Pausova, Z, Rietschel, M, Robbins, T W, Smolka, M N, Schumann, G, Martinot, J-L   +29 more
openaire   +5 more sources

Coping with Childbirth: Brain Structural Associations of Personal Growth Initiative

Frontiers in Psychology, 2017
Major life events require psychological adaptations and can be accompanied by brain structural and functional changes. The goal of the current study was to investigate the association of personal growth initiative (PGI) as a form of proactive coping ...
Judith Mangelsdorf, Judith Mangelsdorf
doaj   +1 more source