Results 61 to 70 of about 130,672 (260)

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Increased Left Putamen Volume Correlates With Pain in Ankylosing Spondylitis Patients

Frontiers in Neurology, 2020
Ankylosing spondylitis (AS) mainly affects the axial skeleton and is an important factor leading to chronic lower back pain in young individuals. However, few studies have explored alterations of brain gray matter volume in AS patients.
Kelei Hua, Kelei Hua, Peijun Wang, Zhihong Lan, Meng Li, Wenkai Zhao, Tianyue Wang, Shumei Li, Xiaofen Ma, Chao Li, Shishun Fu, Yi Yin, Ping Liu, Jin Fang, Jin Fang, Tianwang Li, Guihua Jiang, Guihua Jiang   +17 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Depressive symptoms and neuroanatomical structures in community-dwelling women: A combined voxel-based morphometry and diffusion tensor imaging study with tract-based spatial statistics

NeuroImage: Clinical, 2014
Depressive symptoms, even at a subclinical level, have been associated with structural brain abnormalities. However, previous studies have used regions of interest or small sample sizes, limiting the ability to generalize the results.
Yayoi K. Hayakawa, Hiroki Sasaki, Hidemasa Takao, Naoto Hayashi, Akira Kunimatsu, Kuni Ohtomo, Shigeki Aoki   +6 more
doaj   +1 more source

Moderating effect of cognitive reserve on brain integrity and cognitive performance

Frontiers in Aging Neuroscience, 2022
BackgroundDementia syndrome is one of the most devastating conditions in older adults. As treatments to stop neurodegeneration become available, accurate and timely diagnosis will increase in importance.
Monica E. Nelson, Britney M. Veal, Ross Andel, Ross Andel, Julie Martinkova, Katerina Veverova, Hana Horakova, Zuzana Nedelska, Jan Laczó, Martin Vyhnalek, Jakub Hort   +10 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Reduced gray matter in the prefrontal cortex and hippocampus: a potential neuroanatomical feature of insomnia comorbid with anxiety

Frontiers in Psychiatry
BackgroundChronic insomnia disorder (CID) frequently comorbid with generalized anxiety disorder (GAD), and accurate identification of this comorbidity remains challenging.
Minghe Xu, Yanjie Zhou, Bei Feng, Kunlin Ni, Xinyu Li, Pan He, Qingzhu Zhao, Yu Fan, Li Xiao, Bing Yu   +9 more
doaj   +1 more source

Alterations of brain gray matter volume in children with obstructive sleep apnea

Frontiers in Neurology, 2023
ObjectiveObstructive sleep apnea (OSA) seriously affects the children's cognitive functions, but the neuroimaging mechanism of cognitive impairment is still unclear. The purpose of our study was to explore the difference in brain local gray matter volume
Chenyi Yu, Yuchuan Fu, Yi Lu, Yinyin Huang, Fangfang Chen, Jiayun Wei, Lingling Li, Janet Akoto Ampadu, Yu Wang, Weikun Zheng, Changcan Jiang, Weiyuan Li, Su Lui, Su Lui, Xiaohong Cai   +14 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source