Results 51 to 60 of about 10,411,269 (304)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Gray matter atrophy in multiple sclerosis despite clinical and lesion stability during natalizumab treatment.

PLoS ONE, 2018
BackgroundBrain volume loss is an important surrogate marker for assessing disability in MS; however, contribution of gray and white matter to the whole brain volume loss needs further examination in the context of specific MS treatment.ObjectivesTo ...
Fredrika Koskimäki, Jacqueline Bernard, Jeong Yong, Nancy Arndt, Timothy Carroll, Seon-Kyu Lee, Anthony T Reder, Adil Javed   +7 more
doaj   +1 more source

Lower intelligence quotient and larger brain volume in the precuneus among patients with graves' disease

Taiwanese Journal of Psychiatry, 2023
Objectives: Neuropsychiatric symptoms are related to hyperthyroidism. Whether global cognitive function is impaired is unclear. In this study, we intended to investigate whether patients with Graves' disease (GD) are characterized by a lower intelligence
Kuan-Yu Lai, Shih-Hsien Lin, Huai-Hsuan Tseng, I Hui Lee, Po See Chen, Kao Chin Chen, Shih-Ming Huang, Yen Kuang Yang   +7 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Gray matter atrophy rate as a marker of disease progression in AD [PDF]

, 2010
Global gray matter (GM) atrophy rates were quantified from magnetic resonance imaging (MRI) over 6- and 12-month intervals in 37 patients with Alzheimer's disease (AD) and 19 controls using: (1) nonlinear registration and integration of Jacobian values ...
Miller, David H., Nick C. Fox, Kelvin K. Leung, David H. Miller, Anderson, V.M., Anderson, Valerie M, Jonathan W. Bartlett, Leung, Kelvin K, Bartlett, J.W., Bartlett, Jonathan W., Leung, Kelvin K., Fox, Nick C, Schott, Jonathan M, Leung, K.K., Fox, Nick C., Schott, Jonathan M., Valerie M. Anderson, Fox, N.C., Anderson, Valerie M., Schott, J.M., Bartlett, Jonathan W, Jonathan M. Schott, Miller, David H, Miller, D. H., Schott, JM, Fox, NC, Leung, KK, Miller, DH, Anderson, Valerie, Bartlett, JW   +29 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Increased Left Putamen Volume Correlates With Pain in Ankylosing Spondylitis Patients

Frontiers in Neurology, 2020
Ankylosing spondylitis (AS) mainly affects the axial skeleton and is an important factor leading to chronic lower back pain in young individuals. However, few studies have explored alterations of brain gray matter volume in AS patients.
Kelei Hua, Kelei Hua, Peijun Wang, Zhihong Lan, Meng Li, Wenkai Zhao, Tianyue Wang, Shumei Li, Xiaofen Ma, Chao Li, Shishun Fu, Yi Yin, Ping Liu, Jin Fang, Jin Fang, Tianwang Li, Guihua Jiang, Guihua Jiang   +17 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Depressive symptoms and neuroanatomical structures in community-dwelling women: A combined voxel-based morphometry and diffusion tensor imaging study with tract-based spatial statistics

NeuroImage: Clinical, 2014
Depressive symptoms, even at a subclinical level, have been associated with structural brain abnormalities. However, previous studies have used regions of interest or small sample sizes, limiting the ability to generalize the results.
Yayoi K. Hayakawa, Hiroki Sasaki, Hidemasa Takao, Naoto Hayashi, Akira Kunimatsu, Kuni Ohtomo, Shigeki Aoki   +6 more
doaj   +1 more source

Moderating effect of cognitive reserve on brain integrity and cognitive performance

Frontiers in Aging Neuroscience, 2022
BackgroundDementia syndrome is one of the most devastating conditions in older adults. As treatments to stop neurodegeneration become available, accurate and timely diagnosis will increase in importance.
Monica E. Nelson, Britney M. Veal, Ross Andel, Ross Andel, Julie Martinkova, Katerina Veverova, Hana Horakova, Zuzana Nedelska, Jan Laczó, Martin Vyhnalek, Jakub Hort   +10 more
doaj   +1 more source