Results 41 to 50 of about 1,175,267 (351)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Achievement of ion temperatures in excess of 100 million degrees Kelvin in the compact high-field spherical tokamak ST40

Nuclear Fusion, 2023
Ion temperatures of over 100 million degrees Kelvin (8.6 keV) have been produced in the ST40 compact high-field spherical tokamak (ST). Ion temperatures in excess of 5 keV have not previously been reached in any ST and have only been obtained in much ...
S.A.M. McNamara, O. Asunta, J. Bland, P.F. Buxton, C. Colgan, A. Dnestrovskii, M. Gemmell, M. Gryaznevich, D. Hoffman, F. Janky, J.B. Lister, H.F. Lowe, R.S. Mirfayzi, G. Naylor, V. Nemytov, J. Njau, T. Pyragius, A. Rengle, M. Romanelli, C. Romero, M. Sertoli, V. Shevchenko, J. Sinha, A. Sladkomedova, S. Sridhar, Y. Takase, P. Thomas, J. Varje, B. Vincent, H.V. Willett, J. Wood, D. Zakhar, D.J. Battaglia, S.M. Kaye, L.F. Delgado-Aparicio, R. Maingi, D. Mueller, M. Podesta, E. Delabie, B. Lomanowski, O. Marchuk, the ST40 Team   +41 more
doaj   +1 more source

Portuguese Timor [PDF]

, 1919
"Authorities": p. 26.Mode of access: Internet.Peace handbooks, vol.
Great Britain. Foreign Office. Historical Section
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Depicting urban boundaries from a mobility network of spatial interactions: A case study of Great Britain with geo-located Twitter data

, 2017
Existing urban boundaries are usually defined by government agencies for administrative, economic, and political purposes. Defining urban boundaries that consider socio-economic relationships and citizen commute patterns is important for many aspects of ...
Soliman, Aiman, Wang, Shaowen, Yin, Dandong, Yin, Junjun   +3 more
core   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Enhancing Data Integration with Text Analysis to Find Proteins Implicated in Plant Stress Response

Journal of Integrative Bioinformatics, 2010
High throughput genomic studies can identify large numbers of potential candidate genes, which must be interpreted and filtered by investigators to select the best ones for further analysis. Prioritization is generally based on evidence that supports the
Hassani-Pak Keywan, Legaie Roxane, Canevet Catherine, Berg Hugo A. van den, Moore Jonathan D., Rawlings Christopher J.   +5 more
doaj   +1 more source

The role of plasma–atom and molecule interactions on power & particle balance during detachment on the MAST Upgrade Super-X divertor

Nuclear Fusion, 2023
This paper shows first quantitative analysis of the detachment processes in the MAST Upgrade Super-X divertor (SXD). We identify an unprecedented impact of plasma-molecular interactions involving molecular ions (likely $D_2^+$ ), resulting in strong ion ...
K. Verhaegh, B. Lipschultz, J.R. Harrison, F. Federici, D. Moulton, N. Lonigro, S.P. Kobussen, M. O’Mullane, N. Osborne, P. Ryan, T. Wijkamp, B. Kool, E. Rose, C. Theiler, A.J. Thornton, the MAST Upgrade Team   +15 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Incarcerated Stomach in a Parastomal Hernia

The Annals of African Surgery, 2020
Parastomal hernia is a rare cause of upper gastrointestinal bleeding. We present a case of an 82-year-old lady who presented with a one-month history of abdominal pain associated with coffee ground vomiting and intermittent melena.
Abdelwahed Ahmed, Sochorova Dana, El-Hakim Hisham, Hassan Malek, Zach Rudolf   +4 more
doaj