Results 51 to 60 of about 149,503 (282)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Sparse Polynomial Chaos Expansions via Compressed Sensing and D-optimal Design

, 2017
In the field of uncertainty quantification, sparse polynomial chaos (PC) expansions are commonly used by researchers for a variety of purposes, such as surrogate modeling. Ideas from compressed sensing may be employed to exploit this sparsity in order to
Diaz, Paul, Doostan, Alireza, Hampton, Jerrad   +2 more
core   +1 more source

Adaptive bluetooth indoor positioning system based on greedy strategy

Journal of Physics: Conference Series, 2021
Abstract In order to solve the problem that current bluetooth indoor positioning system has low positioning accuracy in dynamic environment and can’t unable to adapt to dealing with complex situation of anchor circle, this paper proposes an adaptive bluetooth indoor positioning system based on greedy strategy.
Xin Ding, Yawen Dai
openaire   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Constrained Backtracking Matching Pursuit Algorithm for Image Reconstruction in Compressed Sensing

Applied Sciences, 2021
Image reconstruction based on sparse constraints is an important research topic in compressed sensing. Sparsity adaptive matching pursuit (SAMP) is a greedy pursuit reconstruction algorithm, which reconstructs signals without prior information of the ...
Xue Bi, Lu Leng, Cheonshik Kim, Xinwen Liu, Yajun Du, Feng Liu   +5 more
doaj   +1 more source

Finding Minima in Complex Landscapes: Annealed, Greedy and Reluctant Algorithms

, 2004
We consider optimization problems for complex systems in which the cost function has a multivalleyed landscape. We introduce a new class of dynamical algorithms which, using a suitable annealing procedure coupled with a balanced greedy-reluctant strategy
Contucci, Pierluigi, Giardina', Cristian, Giberti, Claudio, Vernia, Cecilia   +3 more
core   +3 more sources

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Neuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Tyrosine kinase inhibitors are the cornerstone of chronic myeloid leukemia treatment. Newer agents have more potency and a broader spectrum of action, but also a higher potential for neuropsychiatric side effects. We present a case of a patient on imatinib who developed progressive cognitive, mood, and behavioral alterations.
Ashley Jones, Samuele Bonomi, Keith E. Stockerl‐Goldstein, Randall J. Bateman   +3 more
wiley   +1 more source

Research on Path Planning Based on Multi-Dimensional Optimized RRT Algorithm

World Electric Vehicle Journal
The Rapidly Exploring Random Tree (RRT) is widely employed in the field of intelligent vehicles, but traditional RRT has issues like inefficient blind expansion, tortuous/discontinuous paths, and slow convergence.
Jinbo Wang, Tongjia Pang, Weihai Zhang, Wei Liao, Tingwei Du   +4 more
doaj   +1 more source

Enhanced Success History Adaptive DE for Parameter Optimization of Photovoltaic Models

Complexity, 2021
In the past few decades, a lot of optimization methods have been applied in estimating the parameter of photovoltaic (PV) models and obtained better results, but these methods still have some deficiencies, such as higher time complexity and poor ...
Yingjie Song, Daqing Wu, Ali Wagdy Mohamed, Xiangbing Zhou, Bin Zhang, Wu Deng   +5 more
doaj   +1 more source