Results 121 to 130 of about 137,035 (279)

Discrete heat kernel, UV modified Green’s function, and higher derivative theories [PDF]

open access: green, 2021
Nahomi Kan   +7 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

A Study of Caputo-Hadamard-Type Fractional Differential Equations with Nonlocal Boundary Conditions

open access: yesJournal of Function Spaces, 2016
Existence and uniqueness results of positive solutions to nonlinear boundary value problems for Caputo-Hadamard fractional differential equations by using some fixed point theorems are presented.
Wafa Shammakh
doaj   +1 more source

Radio-Wave Propagation Model for UHF Band in Different Climatic Conditions with Dyadic Green’s Function [PDF]

open access: diamond, 2015
Cristiane Ruiz Gomes   +4 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

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