Results 121 to 130 of about 8,328 (212)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Bayesian source localization with uncertain Green’s function
, 2015 International audienceThe localization of an acoustic source in the oceanicwaveguide is a difficult task because the oceanic environmentis often poorly known.
Gall, Yann Le +3 more
core
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
On Some Inequalities with Higher Fractional Orders
Fractal and FractionalThe novelty herein pertains to a class of fractional differential equations involving the Hadamard fractional derivative of higher order. Our investigation encompasses the fractional integral operator of a logarithmic function.
Lakhdar Ragoub
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Bounds for the two-dimensional discrete harmonic Green’s function
, 1966 Estimation of bounds for the two-dimensional discrete harmonic Green’s function is obtained. These estimations can then be used to obtain approximate solutions to two-dimensional boundary problems associated with the harmonic difference operator.
Moshe Mangad
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
New Green’s function for stress field and a note of its application in quantum-wire structures
, 2009 The elastic field caused by the lattice mismatch between the quantum wires and the host matrix can be modeled by a corresponding two-dimensional hydrostatic inclusion subjected to plane strain conditions.
Jin, Xiaoqing +5 more
core +1 more source
GREEN'S FUNCTION FOR RIGIDLY FIXED PLATE
Structural Mechanics of Engineering Constructions and Buildings, 2010 A problem of finding of displacements of a rigidly fixed plate loaded by concentrated force is examined. As an example, there was taken a triangle plate for which the function of Green was built with the help of the system «Mathematica».
Alexandr Alexandrovitch Timofeyev
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source