Results 51 to 60 of about 1,149,319 (336)

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Spectrum generating algebra for the pure spinor superstring

open access: yes, 2014
In this work, a DDF-like construction within the pure spinor formalism is presented. Starting with the light-cone massless vertices, the creation/annihilation algebra is derived in a simple manner, enabling a systematic construction of the physical ...
Jusinskas, Renann Lipinski
core   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

On the theory of cavities with point-like perturbations. Part I: General theory [PDF]

open access: yes, 2008
The theoretical interpretation of measurements of "wavefunctions" and spectra in electromagnetic cavities excited by antennas is considered. Assuming that the characteristic wavelength of the field inside the cavity is much larger than the radius of the ...
Albeverio S   +17 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

From artificial intelligence adoption to enterprise green development: Does dual environmental turbulence matter?

open access: yesInternational Review of Economics & Finance
In the context of the global resource crisis, resource-based enterprises green transformation is a key way to achieve the “dual-carbon” goal, in which artificial intelligence (AI) adoption plays an increasingly important role.
Miao Wang, Qing Xia, Shouxun Wen
doaj   +1 more source

The Green Function for the BFKL Pomeron and the Transition to DGLAP Evolution [PDF]

open access: yes, 2014
We consider the (process-independent) Green function for the BFKL equation in the next-to-leading order approximation, with running coupling, and explain how, within the semi-classical approximation, it is related to Green function of the Airy equation ...
Kowalski, Henri   +2 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

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