Results 121 to 130 of about 137,997 (282)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

FRENCH-ROMANIAN WORKSHOP “PROMOTING GREEN CHEMISTRY” 06 – 07 JULY 2010 – ORLEANS, FRANCE

Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2011
The French-Romanian Workshop "Promotion of Green Chemistry - Applications in Organic Synthesis, Analytical Chemistry and Process Engineering" organized by the Research Center “Applied Chemistry and Process Engineering” of the "Vasile Alecsandri ...
Irina-Claudia Alexa
doaj  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Green Chemistry Within the Circular Bioeconomy to Harness Chestnut Burr Extract’s Synergistic Antimicrobial Activity Against Helicobacter pylori

Green chemistry principles are pivotal in driving sustainable and innovative solutions to global health challenges. This study explores a hydroalcoholic extract from Castanea sativa (chestnut) burrs, an underutilized natural resource, as a potent source ...
Maria Lucia Schiavone, Annalisa Santucci, Roberta Barletta, Lia Millucci, Michela Geminiani, Alfonso Trezza, Natale Figura   +6 more
core   +1 more source

Replacement of Hazardous Solvents and Reagents in Analytical Chemistry

, 2011
This chapter presents numerous alternatives to solvents and reagents for analytical chemistry. Solvents alone often account for most of the waste generated by analytical methods, especially through sample preparation and mobile phases.
Douglas E. Raynie, Jennifer L. Young
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Latest trends in honey contaminant analysis, challenges, and opportunities for green chemistry development [PDF]

The latest advances in honey trace contaminants analysis according to 70 articles gathered, mainly from the last 4 years, are critically reviewed, focusing on green and environmentally friendly aspects.

core  

Hydrogel Electrolytes-Based Rechargeable Zinc-Ion Batteries under Harsh Conditions

Nano-Micro Letters
Highlights The developing history and recent advances of hydrogel electrolytes for rechargeable zinc-ion batteries under harsh conditions are summarized. The fundamentals, species, and mechanisms of the hydrogel electrolytes are discussed. The functional
Zhaoxi Shen, Zicheng Zhai, Yu Liu, Xuewei Bao, Yuechong Zhu, Tong Zhang, Linsen Li, Guo Hong, Ning Zhang   +8 more
doaj   +1 more source

Integrating green and white analytical principles for endocrine disruptor analysis in aqueous matrices: From routine methods to emerging technologies

Green Analytical Chemistry
The field of research and development offers promising opportunities to optimize sample preparation and analysis in the determination of endocrine disrupting chemicals.
Michelle Klein, Martin Daniel Klassen, Torsten Claus Schmidt, Jochen Tuerk   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source