Results 101 to 110 of about 76,599 (297)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Green chemistry and sustainable development

Prayogik Rasayan, 2020
Chemistry is truly very helpful to us as its applications are used globally for numerous purposes. Almost all products have been manufactured involving one or more chemical processes. Therefore, we cannot imagine our life without the products produced by the chemical industry. However, to obtain our desired products, always a large amount of wastes and
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Red chemistry: Principles and applications

Next Sustainability
There is a growing concern regarding the lack of sufficient justification for claims of ''greenness'' in research studies. This concern has sparked heated debates and prompted calls for mandatory discussions on adherence to green chemistry principles in ...
Swapnil L. Fegade
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

CoOx Nano-clusters anchored onto 10-membered ring of Silicate-1 boost propane dehydrogenation

Nature Communications
Cobalt-zeolites catalysts for propane dehydrogenation (PDH) suffer from low activities on the confined Co sites in zeolites or poor stabilities on the CoOx species in presence of hydrogen. In this work, we synthesize a unique Co structure with (≡Si-O)2Co(
Ruiqiang Liu, Bing Ma, Linlong Zhang, Jingqing Tian, Chen Zhao   +4 more
doaj   +1 more source

Preparation and Testing of Polyethylenimine-Impregnated Silica Gel for CO₂ Capture

Gels
This work studied the low-temperature sorption of carbon dioxide on impregnated silica gel. An impregnating agent was used polyethyleneimine. The content of the impregnating agent in the silica gel matrix was 33.4 wt.%.
Veronika Kyselová, Jakub Havlín, Karel Ciahotný   +2 more
doaj   +1 more source

Green Chemistry in Brazilian lecturer graduation: Mapping and its importance at teaching practice

Amazônia, 2019
The philosophy of Green Chemistry or sustainable Chemistry could be described as a creation, development and application of a product or a process in order to reduce or eliminate te use and generation of hazardous materials. The aim of a teacher training
Queli Aparecida Rodrigues de Almeida, Bianca Bassetti Silva, Geovani Aristeu Lima Silva, Suelen Stutz Gomes, Thaina Nascimento da Conceição Gomes   +4 more
doaj   +1 more source

Sustainable green chemistry Green chemical processing ;, vol. 1./ edited by Mark Anthony Benvenuto.

, 2017
Includes bibliographical references and index."Sustainable Green Chemistry, the 1st volume of Green Chemical Processing, covers several key aspects of modern green processing.
Benvenuto (Mark Anthony),
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