Results 91 to 100 of about 2,552,917 (288)

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Quantitative Analysis of Urban Canyon Morphology Impacts on Summer Outdoor Thermal Comfort: A Case Study of Chongqing, China

open access: yesBuildings
In the context of global climate change and rapid urbanization, urban outdoor thermal environment issues in summer have become increasingly severe. Shading has been widely recognized as an effective strategy for improving outdoor thermal comfort, yet ...
Tiantian Xu   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Prospect Green Map: a community map of environmental, historical, cultural, civic, and recreational sites

open access: yes
A map detailing the sites of interest and importance in the Prospect, NC, and the Robeson County area of North Carolina.
Robeson County Green Map Project
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Multi-Faceted Analysis of Green Building Certification to Expand Green Buildings in South Korea

open access: yesBuildings
Many countries have green building certification systems to rate a green building. They have played a pivotal role in promoting the adoption of green buildings.
Young-Sun Jeong
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Report on carbon reductions in new non-domestic buildings [PDF]

open access: yes, 2007
This report investigates the opportunities for achieving zero carbon new non-domestic buildings. Although this is an important element in reducing the carbon emissions associated with non-domestic buildings, it does not present the whole picture. Given
UK Green Building Council
core  

Experimental investigation on performance enhancement of damaged tunnel segments using AFRP sheet strengthening

open access: yesResults in Engineering
This study investigates the strengthening of damaged subway tunnel segments using aramid fiber-reinforced polymer (AFRP) plates, aiming to leverage their ease of installation and favorable tensile properties to mitigate serviceability issues such as ...
Kan Huang   +7 more
doaj   +1 more source

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