Results 91 to 100 of about 3,717,502 (395)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Strategic green infrastructure planning in Germany and the UK: a transnational evaluation of the evolution of urban greening policy and practice [PDF]

, 2017
The evolution of Green Infrastructure (GI) planning has varied dramatically between nations. Although a grounded set of principles are recognized globally, there is increasing variance in how these are implemented at a national and sub-national level. To
Ahern J., Albert C., Austin G., BBSR, Beatley T., Benedict M. A., Benedict M. A., Blackman D., Blotevogel H. H., BMU (Bundesministerium für Umwelt, Naturschutz und Reaktorsicherheit), BMUB (Bundeministerium für Umwelt, Naturschutz, Bau und Reaktorsicherheit., Bundesregierung, CABE Space, Cullingworth B., Davies C., Department of Communties and Local Government, Department of Environment Transport and the Regions, European Commission, Fürst D., Gailing L., Hansen R., Ian Mell, Jost Wilker, Kiwitt T., Mario Reimer, Mazza L., McHarg I. L., Mell I. C., Mell I. C., Mell I. C., Mertins G., Natural England &, Office of the Deputy Prime Minister, Pahl-Weber E., Projekt Ruhr GmbH (Ed.), Reimer M., Riedel W., Rouse D. C., RVR, Siemens AG, Simone Allin, South Yorkshire Forest Partnership &, Staatskanzlei des Landes Nordrhein-Westfalen (NRW), Town &, von Haaren C., Ward Thompson C., Werquin A. C., Wilker J., Wright H.   +48 more
core   +2 more sources

Urban heat mitigation by green and blue infrastructure: Drivers, effectiveness, and future needs

Innovation (Cambridge (Mass.))
The combination of urbanization and global warming leads to urban overheating and compounds the frequency and intensity of extreme heat events due to climate change.
Prashant Kumar, Sisay E. Debele, Soheila Khalili, Christos H. Halios, J. Sahani, N. Aghamohammadi, Maria de Fátima Andrade, Maria Athanassiadou, Kamaldeep Bhui, N. Calvillo, Shi-Jie Cao, Frederic Coulon, Jill L. Edmondson, David Fletcher, Edmilson Dias de Freitas, Hai Guo, M. C. Hort, Madhusudan Katti, T. R. Kjeldsen, Steffen Lehmann, G. M. Locosselli, S. Malham, Lidia Morawska, Rajan Parajuli, C. Rogers, Runming Yao, Fang Wang, Jannis Wenk, Laurence Jones   +28 more
semanticscholar   +1 more source

Environmental justice implications of siting criteria in urban green infrastructure planning

Journal of Environmental Policy and Planning, 2021
Green infrastructure (GI) has become a panacea for cities working to enhance sustainability and resilience. While the rationale for GI primarily focuses on its multifunctionality (e.g.
F. Hoover, Sara Meerow, Z. Grabowski, T. McPhearson   +3 more
semanticscholar   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Nitrogen-Doped Calcite Derived from Ca-MOFs as an Efficient Adsorbent for Sr(II) Removal from Water: The Role of Nitrogen and Calcium

Clean Technologies
Strontium (90Sr) is a typical radionuclide, which can act as a contaminant and poses a big problem for the eco-environment if left untreated. In this study, an original nitrogen-doped calcite (N-CaCO3) was synthesized using a solvothermal and calcination
Xinran Xie, Guoce Yu, Jiangbo Huo, Xinbo Zhang, Qing Du   +4 more
doaj   +1 more source

Theoretical Basis of the Green Infrastructure Strategy: International Experience

Людина і довкілля: Проблеми неоекології, 2019
The Green Infrastructure Strategy is used in different directions related to the design, protection and protection of the environment. Purpose. Analyze international experience in using the concept of green infrastructure, identify the main theoretical ...
N. V. Maksymenko, S. V. Burchenko
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

WSN infrastructure for green campus development [PDF]

, 2016
A system providing accurate environmental data for campus stakeholders to formulate and evaluate policies of the sustainable campus development is needed.
Nurhayati, Oky Dwi, Rochim, Adian Fatchur, Sumardi, Sumardi, Widianto, Eko Didik   +3 more
core  

The Air-temperature Response to Green/blue-infrastructure Evaluation Tool (TARGET v1.0) : an efficient and user-friendly model of city cooling [PDF]

, 2019
The adverse impacts of urban heat and global climate change are leading policymakers to consider green and blue infrastructure (GBI) for heat mitigation benefits.
Broadbent, Ashley M, Coutts, Andrew M, Demuzere, Matthias, Krayenhoff, E Scott, Nice, Kerry A, Tapper, Nigel J, Wouters, Hendrik   +6 more
core   +1 more source