Results 241 to 250 of about 765,207 (307)

Mitochondria limit coenzyme Q export under cholesterol biosynthetic stress. [PDF]

J Cell Biol
Ndoci M, Bhattacharya S, Agrawal I, Hinze Y, Lemke K, Schumacher AL, Uijttewaal E, Elling U, Lawo S, Giavalisco P, Langer T, Deshwal S.   +11 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Unpredictable sound stress induces a novel form of hyperalgesic priming. [PDF]

Pain
Araldi D, Green PG, Levine JD.
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

A multi-faceted study combining quantum chemical, Hammett parameters, and antibacterial assessment for imidazole: based green ionic liquids corrosion inhibition. [PDF]

BMC Chem
Moustafa AHE, Abdel-Rahman HH, Hagar M, Bishr SAA.   +3 more
europepmc   +1 more source

Personalized Drug Screening and Risk Assessment in Patient-Derived Gastroenteropancreatic Neuroendocrine Neoplasms.

J Clin Endocrinol Metab
Auernhammer CJ, Wang K, Maccio U, Knösel T, Hungbauer MP, Schilbach K, Maurer J, Peischer L, Reul A, Kuzmenko E, Luca E, Hamati J, Vetter D, Oberholzer J, Fritsch R, Pacak K, Grossman AB, Beuschlein F, Reincke M, Hantel C, Zitzmann K, Nölting S.   +21 more
europepmc   +1 more source

Targeting Selectivity: Improving Golgi α-Mannosidase II (GMII) Inhibitors Through In Silico Studies. [PDF]

Biomolecules
Ledesma NG, Nieto CT, Manchado A, Castro MÁ, Diez D.   +4 more
europepmc   +1 more source

Crystal structure of human INPP5K with an allosteric inhibitor reveals the structural basis for species specific potency. [PDF]

Sci Rep
Nomura A, Yamaguchi K, Kawano M, Hanada K, Nishihata J, Noguchi M, Adachi T.   +6 more
europepmc   +1 more source

Efficacy and safety of upadacitinib in the treatment of rheumatoid arthritis: a systematic review and meta-analysis. [PDF]

Front Immunol
Xu YH, Liu D, Zhang MR, Zhang YJ, Li M, Yang QR.   +5 more
europepmc   +1 more source