Results 71 to 80 of about 779,813 (264)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Synthesis of self-healing Smart Epoxy and Polyurethane Coating by Encapsulation of Olive Leaf Extract as Corrosion Inhibitor

International Journal of Electrochemical Science, 2018
Self-healing coatings with the ability of recovering damaged areas, have a high potential application in corrosion prevention, because of high reliability and cost reductions. In this research, fabrication and characterization of epoxy and urethane based
Zahra Jamshidnejad, Abdollah Afshar, Mohammad Amin RazmjooKhollari   +2 more
doaj   +1 more source

Synthesis and Mechanism of a Green Scale and Corrosion Inhibitor

International Journal of Molecular Sciences
A new green water treatment agent, a poly(aspartic acid)-modified polymer (PASP/5–AVA), was synthesized using polysuccinimide and 5-aminovaleric acid (5-AVA) in a hybrid system. The structure was characterized, and the scale and corrosion inhibition performance were carried out with standard static scale inhibition and electrochemical methods ...
Linlin Zhao, Yu Han, Xiaojuan Zhang, Zhongyan Cao, Xiaowei Zhao, Yuxia Wang, Yonghong Cai, Yufeng Wu, Ying Xu   +8 more
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Allium sativum as Corrosion Inhibitor for Carbon Steel in Sulfuric Acid

International Journal of Electrochemical Science, 2014
A study on the use of Allium sativum (garlic) as corrosion inhibitor for carbon steel in 0.5M H2SO4 has been carried out by using potentiodynamic polarization curves, electrochemical impedance spectroscopy and weight loss measurements.
E. Rodriguez-Clemente, J.G. Gonzalez-Rodriguez, M.G. Valladares-Cisneros   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Influence of pH on the Use of Salvia Hispanica as Green Corrosion Inhibitor for Carbon Steel in Sulfuric Acid

International Journal of Electrochemical Science, 2017
The use of Salvia hispanica as a green corrosion inhibitor for 1018 carbon steel in 0.5 M H2SO4 solution at different pH values has been evaluated using weight loss tests, potentiodynamic polarization curves and electrochemical impedance spectroscopy ...
E.A. Flores-Frias, J. Porcayo-Calderon, M.A. Lucio-Garcia, J.G. Gonzalez-Rodriguez, L. Martinez-Gomez   +4 more
doaj   +1 more source