Results 31 to 40 of about 377,973 (217)

Container Liner Shipping System Design Considering Methanol-Powered Vessels

Journal of Marine Science and Engineering
The transition from the use of heavy fuel oil (HFO) to the use of green fuels (e.g., methanol) for container liner shipping presents a significant challenge for liner shipping system design (LSSD) in terms of achieving emission reductions. While methanol,
Zhaokun Li, Xinke Yu, Jianning Shang, Kang Chen, Xu Xin, Wei Zhang, Shaoqiang Yu   +6 more
doaj   +1 more source

In-vitro Antibacterial Activities of Selected Traditional Plants

Journal of Pure and Applied Microbiology, 2018
The present research work was focused on the antibacterial activity of medicinal plants (Aegle marmelos, Citrus aurantifolia, Piper sarmentosum, Sesbania grandiflora, Carthamus tinctorius, Piper longum, Morus alba, Green tea and Oolong tea).
Jeeranun Untachai, Wanwisa Dodgson, Akeapot Srifa, Jolyon L. A. Dodgson   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A Study on the Limitations of Green Alternative Fuels in Global Shipping in the Foreseeable Future

Journal of Marine Science and Engineering
Shipping carries over 80% of global trade volumes and emits 3% of global greenhouse gas emissions, but it is hard to abate due to the simple fact that ships require a lot of energy and move around. Therefore, a large amount of research and development is
Jan Emblemsvåg
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Enhancing Green Methanol Production via CO2 Hydrogenation: Process Intensification using Plug Flow Reactor and Vanden Bussche-Froment

Journal of Chemical Engineering Research Progress
The transition to renewable energy in Indonesia requires strategic solutions for carbon capture and utilization (CCU). Methanol synthesis from captured CO2 and green hydrogen offers a promising pathway but is hindered by thermodynamic equilibrium ...
Faiz Fairuz Zaki, Alifio Alifio, Muhammad Nur Irfan, Job Boas, Maulana Nizar Amrullah, Hanif Farrel Ardan   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Methanol Production Pathways in Nova Scotia: Opportunities and Challenges for Carbon Capture, Utilization, and Storage

Energies
Producing methanol through carbon capture and utilization presents a sustainable alternative to traditional methods. This study explores two main production pathways, which are further divided into four distinct scenarios.
Augustine Okafor, Larry Hughes
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source