Results 41 to 50 of about 363,078 (257)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Container Liner Shipping System Design Considering Methanol-Powered Vessels

Journal of Marine Science and Engineering
The transition from the use of heavy fuel oil (HFO) to the use of green fuels (e.g., methanol) for container liner shipping presents a significant challenge for liner shipping system design (LSSD) in terms of achieving emission reductions. While methanol,
Zhaokun Li, Xinke Yu, Jianning Shang, Kang Chen, Xu Xin, Wei Zhang, Shaoqiang Yu   +6 more
doaj   +1 more source

Assessing the economic viability of green methanol production: The critical role of CO2 purity in green methanol production

Systems and Control Transactions
The growing concern over climate change and rising carbon dioxide (CO2) emissions have spurred the development of strategies to upcycle greenhouse gases. One promising solution is the synthesis of green methanol via catalytic hydrogenation of captured CO2 using renewable hydrogen (H2).
Franc Gonz�lez-Cazorla, Jordi Pujol, Oriol Mart�nez, Lluis Soler, Mois�s Graells   +4 more
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A Study on the Limitations of Green Alternative Fuels in Global Shipping in the Foreseeable Future

Journal of Marine Science and Engineering
Shipping carries over 80% of global trade volumes and emits 3% of global greenhouse gas emissions, but it is hard to abate due to the simple fact that ships require a lot of energy and move around. Therefore, a large amount of research and development is
Jan Emblemsvåg
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Enhancing Green Methanol Production via CO2 Hydrogenation: Process Intensification using Plug Flow Reactor and Vanden Bussche-Froment

Journal of Chemical Engineering Research Progress
The transition to renewable energy in Indonesia requires strategic solutions for carbon capture and utilization (CCU). Methanol synthesis from captured CO2 and green hydrogen offers a promising pathway but is hindered by thermodynamic equilibrium ...
Faiz Fairuz Zaki, Alifio Alifio, Muhammad Nur Irfan, Job Boas, Maulana Nizar Amrullah, Hanif Farrel Ardan   +5 more
doaj   +1 more source

Thermal stability data of juglone from extracts of walnut (Juglans regia) green husk, and technologies used to concentrate juglone

Data in Brief, 2019
The data presented in this article are focused on thermal stability data of both juglone standard (in ethanol and methanol) and a natural extract containing juglone from lyophilized walnut green husk (in ethanol and methanol).
Eduardo Caballero, Carmen Soto, John Jara   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source