Results 111 to 120 of about 659,868 (301)

Telomere‐to‐Telomere Genomes Reveal that Multiscale Evolution Shapes the Largest Metabolic Arsenal of Diaporthe Fungi

Advanced Science, EarlyView.
This study presents the first telomere‐to‐telomere genomes and population resources for Diaporthe pathogens, uncovering the largest known fungal repertoire of secondary metabolite gene clusters. Structural variations and horizontal gene transfer drive cluster diversification, while specific rapidly evolving clusters control virulence, offering novel ...
Kainan Li, Chen Zhang, Zhichao Zhang, Jiaheng Cheng, Qiuyan Gao, Long Gao, Xiaolin Zhao, Wei Yan, Yuanchao Wang, Wenwu Ye   +9 more
wiley   +1 more source

Difficult-to-float lignite reverse flotation based on forced pre-mudding

矿业科学学报
Lignite is prone to mudding and poor separation effect in direct flotation. This study puts forward a lignite flotation method of forced mudding combined with reverse flotation for efficient ash reduction and quality improvement of difficult-to-float ...
LI Yunchang, XIA Yangchao, LI Ao, WANG Hao, BUDEEBAZAR Avid, XING Yaowen, GUI Xiahui   +6 more
doaj   +1 more source

Paving the Way to Elucidate Hg's Role in Tumorigenesis

Advanced Science, EarlyView.
Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li, Rong Zhong, Zhenyang Yu, Hualing Fu, Jin Chen, Jia Wei, Ningwei Zhao, Le Qu, Tiantian Li, Wenli Tang, Huan Zhong   +10 more
wiley   +1 more source

Structural Performance Warning Based on Computer Intelligent Monitoring and Fractional-Order Multi-Rate Kalman Fusion Method

Fractal and Fractional
When bridge towers are subjected to strong winds, they exhibit significant displacements. This displacement change can serve as an important indicator for structural performance warning.
Yan Wang, Yan Shi, Taoyuan Yang, Weinan Wang, Zhongmiao Sun, Yuqi Zhang   +5 more
doaj   +1 more source

Shared Value in Chile: Increasing Private Sector Competitiveness by Solving Social Problems [PDF]

, 2014
Over the last few decades, Chile has experienced rapid and sustained economic, social, and institutional development. Crucial challenges remain, however, in the form of social inequity, lack of opportunity, mistrust, and social unrest.
Arani Kajenthira Grindle, Dane Smith, Marina Pol Longo, Michael Murray   +3 more
core  

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source

Metabologenomic Hallmark‐Based Discovery of Bacterial Thioamides as a New Lead against Drug‐Resistant Pancreatic Cancer

Advanced Science, EarlyView.
A targeted metabologenomic strategy integrating genomic and metabolomic hallmarks enabled the discovery of two new thioamides, thiogochangamides A and B, from bacteria. Their absolute configurations, previously unresolved within the thioviridamide family, were fully assigned through various chemical derivatizations and computational analysis ...
Young Eun Du, Eun Seo Bae, Thinh T. M. Bui, Seok Beom Lee, Dahan Kim, Jin‐Gyeong Park, Yongjoo Park, Soo Yeon Park, Sangwook Kang, Beomsu Lee, Daniel Shin, Yun Pyo Kang, In‐Gyun Lee, Dae‐Duk Kim, Seokhee Kim, Suckchang Hong, Kyuho Moon, Sang Kook Lee, Dong‐Chan Oh   +18 more
wiley   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Bearing characteristics and control measures of coal rib under the condition of composite roof in deep mining

Scientific Reports
In response to the problem of low bearing capacity of soft coal support in deep mining, which leads to deformation and instability of composite roof, a comprehensive analysis of coal support stability was conducted through on-site research, mechanical ...
Sen Yang, Xiangqian Wang, Qingheng Gu, Junzhi Chen   +3 more
doaj   +1 more source

Objective determination of initiation stress and damage stress in rock failure using acoustic emission and digital image correlation

Alexandria Engineering Journal
Crack initiation stress and damage stress are two critical characteristic stresses in the rock failure process, and their precise determination is essential for a comprehensive understanding of the progressive failure mechanisms of rocks.
Peng Liang, Yanbo Zhang, Xulong Yao, Guangyuan Yu, Qiang Han, Junling Liu   +5 more
doaj   +1 more source