Results 81 to 90 of about 82,086 (215)

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

Bearing characteristics and control measures of coal rib under the condition of composite roof in deep mining

Scientific Reports
In response to the problem of low bearing capacity of soft coal support in deep mining, which leads to deformation and instability of composite roof, a comprehensive analysis of coal support stability was conducted through on-site research, mechanical ...
Sen Yang, Xiangqian Wang, Qingheng Gu, Junzhi Chen   +3 more
doaj   +1 more source

Objective determination of initiation stress and damage stress in rock failure using acoustic emission and digital image correlation

Alexandria Engineering Journal
Crack initiation stress and damage stress are two critical characteristic stresses in the rock failure process, and their precise determination is essential for a comprehensive understanding of the progressive failure mechanisms of rocks.
Peng Liang, Yanbo Zhang, Xulong Yao, Guangyuan Yu, Qiang Han, Junling Liu   +5 more
doaj   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

Carbon sources/sinks and emission reduction and sink enhancement in green mining

Meitan xuebao
In response to the long-standing environmental problems caused by mining, some green mining concepts and policies have been gradually developed.
Jinman WANG, Man YANG, Biao LIU, Qiuping ZHU   +3 more
doaj   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

Action mechanism of suspending agent content on strength property of cemented backfill in coal mine

Scientific Reports
In order to reduce the segregation degree of cemented backfilling slurry in coal mine and enable cemented backfill in coal mine (CBCM) to normally exert its load-bearing capacity, uniaxial compressive strength test, static segregation index test and ...
Haigang Yang, Rui Wang, Qiang Zhang, Shanshan Guo, Yukai Wang   +4 more
doaj   +1 more source

How Advanced Artificial Intelligence Technologies Shape Drug–Drug and Drug–Target Interaction Modeling

Advanced Science, EarlyView.
This review explores the convergence of artificial intelligence technologies in modeling drug–drug and drug–target interactions. By evaluating advanced feature engineering, architectural innovations, and learning paradigms reveals shared evolutionary trends and critical challenges, such as cold‐start settings and shortcut learning.
Xin Sun, Tong Wang
wiley   +1 more source

Research on emulsion concentration detection technology based on interpretable machine learning methods

Results in Engineering
Emulsion plays a critical role in ensuring the normal operation of hydraulic equipment and coal mine safety. However, existing underground emulsion concentration detection modules suffer from high failure rates and insufficient accuracy.
Jiaxu Kang, Jianwei Li, Meng Wang, Xinwei Guo, Dinghao Liu, Chao Qu, Chengbin Guo   +6 more
doaj   +1 more source