Results 151 to 160 of about 1,297,191 (300)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Creative Commons Open Education, Open Access, and Librarians
, 2013 Dr Cable Green, Director of Global Learning for Creative Commons, leads a wide-ranging discussion with ASERL members about the use of Creative Commons tools to foster greater access to knowledge objects and open educational resources (OERs)
Green, Cable
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Conference Institutional archives for research: experiences and projects in Open Access Istituto Superiore di Sanità Rome, 30 November - 1 December 2006 [PDF]
, 2007 The Congress was organised into four sessions: 1) Open Access (OA) and authors: support from the international community; 2) OA in Italy: knowledge and tools to write and search; 3) institutional policies for OA; 4) opportunities and services to develop ...
Paola, De Castro
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
BiD: Textos Universitaris de Biblioteconomia i Documentació, 2007 La principal característica de open access consiste en que el aprovechamiento del conocimiento procedente del ámbito de educación y ciencia, que ha sido hecho público y se ha producido con fondos públicos, es libre (también en el sentido deThe main ...
Kuhlen, Rainer
doaj
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Maximizing Research Impact Through Institutional and National Open-Access Self-Archiving Mandates
, 2006 No research institution can afford all the journals its researchers may need, so all articles are losing research impact (usage and citations). Articles made “Open Access,” (OA) by self-archiving them on the web are cited twice as much, but only 15% of ...
Harnad, Stevan
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