Results 161 to 170 of about 1,826,217 (302)

Gene burden meta‐analysis of 748 879 individuals identifies LGI1‐ADAM23 protein complex association with epilepsy

Epilepsia, EarlyView.
Abstract Epilepsy affects more than 50 million individuals globally and has a substantial genetic component that remains to be completely understood. Traditional studies have focused on severe, early onset cases enrolled through clinical or research settings.
Jessica Castrillon Lal, Costin Leu, Christian M. Boßelmann, Alina Ivaniuk, Eduardo Pérez‐Palma, Dennis Lal   +5 more
wiley   +1 more source

A translational multimodal machine‐learning prototype predicting valproate response in epilepsy treatment

Epilepsia, EarlyView.
Abstract Objective Epilepsy affects ~1% of the global population and often requires lifelong antiseizure medication (ASM) therapy. Valproic acid (VPA) is a commonly prescribed first‐line ASM, yet only approximately half of patients achieve sustained seizure freedom. Treatment selection remains largely empirical.
Simeon Platte, Afsheen Kumar, Giorgia Guerini, Massimo Pandolfo, Denise Haslinger, Colin B. Josephson, Guillermo Delgado‐García, Navprabhjot Kaur, Michaela‐Pauline Lux, Heiko Stempfle, Chantal Depondt, Reetta Kälviäinen, Felix Rosenow, Sophie von Brauchitsch, Karl Martin Klein, Andreas G. Chiocchetti   +15 more
wiley   +1 more source

Differential selectivity of microglia and astrocytes in HIV-1 gp120-induced synaptic pruning. [PDF]

Brain
Watson ZT, Valdebenito-Silva S, Spurgat M, Ru W, Zheng J, Maurelli MK, Liang Y, Yuan S, Eugenin E, Tang SJ.   +9 more
europepmc   +1 more source

AI‐based localization of the epileptogenic zone using intracranial EEG

Epilepsia Open, EarlyView.
Abstract Artificial intelligence (AI) is rapidly transforming our lives. Machine learning (ML) enables computers to learn from data and make decisions without explicit instructions. Deep learning (DL), a subset of ML, uses multiple layers of neural networks to recognize complex patterns in large datasets through end‐to‐end learning.
Atsuro Daida, Yipeng Zhang, Sotaro Kanai, Richard Staba, Vwani Roychowdhury, Hiroki Nariai   +5 more
wiley   +1 more source

Large language model assisted decision support framework for uncertainty aware detection and management of tomato lateral shoots. [PDF]

Front Plant Sci
Jiang Y, Geng Y, Zheng Z, Pang X.
europepmc   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Electroacupuncture prevents CUMS induced depressive-like behaviors by inhibiting microglia-mediated synaptic pruning induced by gut dysbiosis. [PDF]

Chin Med
Zhang L, Quan J, Nie L, He S, Lin Y, Liu X, Zhang Y, Zhuang L, Jia C, Li M, Wang Q, Duan L.   +11 more
europepmc   +1 more source

Photodynamic Biomimetic Nanoparticles Accelerate Tumor Vascular Normalization Initiation

Exploration, EarlyView.
Platelet‐mimetic IA@PM integrates apatinib‐driven vascular normalization with ICG‐mediated photodynamic therapy, creating a self‐amplifying vascular normalization therapy (VNT)–photodynamic therapy (PDT) cycle that accelerates the onset of the vascular normalization window and potentiates antitumor treatment.
Yufei Liu, Changheng Xie, Yanfeng Huang, Ting Wang, Shi Du, Hui Xiong, Jing Yao   +6 more
wiley   +1 more source

The Fractalkine (FKN/CX3CL1) Pathway in Depression: A Critical Review of Its Role in Neuroinflammation and Therapeutic Potential. [PDF]

Neuropsychiatr Dis Treat
YanLuan Z, Sa R, Fan Y, Jia H, Ge J, Bai S, Ma R, Tong L.   +7 more
europepmc   +1 more source

Grading Bamboo Pruning Pellets

The cultivation of bamboo has been attracting increasing attention in Europe, recently. Bamboo is appreciated for its aesthetic value in ornamental gardening and is being increasingly used for textiles, flooring and furniture.
Mirko Maraldi, Valda Rondelli, Alessio Mencarelli, Stefano Grigolato, Rosa Greco   +4 more
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