Results 91 to 100 of about 344,814 (256)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Towards a greener future: The role of sustainable methodologies in metabolomics research

Advances in Sample Preparation
Sustainability is a growing priority in scientific research, and metabolomics is no exception. Traditional metabolomics workflows rely on hazardous solvents, raising concerns regarding their environmental impact.
Chiara Spaggiari, Kgalaletso Othibeng, Fidele Tugizimana, Gabriele Rocchetti, Laura Righetti   +4 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

New green base for Fmoc removal in solid-phase peptide synthesis: 1,5-diazabicyclo[4.3.0]non-5-ene (DBN), a promising sustainable alternative to piperidine

Green Chemistry Letters and Reviews
Developing greener synthetic methodologies requires replacing hazardous reagents with more sustainable alternatives. In solid-phase peptide synthesis (SPPS), piperidine is the standard base for Fmoc group removal, but its toxicity, environmental concerns,
Maria Carmina Scala, Giovanni Vivenzio, Michele Manfra, Marina Sala, Pietro Campiglia   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

COMPARATIVE STUDIES OF SOLVATOCHROMISM BEHAVIOUR OF COPPER(I1) AND NICKEL(I1) SCHIFF BASE COMPLEXES [PDF]

Journal of Sciences, Islamic Republic of Iran, 1999
A series of Schiff Bases of Ni(II) and Cu(II) using acetylacetone (acac), salicylaldehyde (sal), ethylenediamine (en), and o-phenylendiarnine (dabe) were prepared and characterized.
doaj  

Valorization of Camellia oleifera through integrated lignin extraction and tunable nanoparticle synthesis

AIP Advances
The high-value utilization of Camellia oleifera, a major agroforestry waste, is critical for sustainable biomass management. This study presents a green integrated process for efficient lignin extraction and controllable nanoparticle synthesis via acidic
Yougen Wu, Chengyun Deng, Xiaolu Zhao, Zhiping Wu, Zhenyan Ma, Hui Wang, Lishu Shao, Lin Zhang   +7 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source