Results 71 to 80 of about 347,931 (304)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Solubilization and Thermodynamic Analysis of Isotretinoin in Eleven Different Green Solvents at Different Temperatures

, 2022
The solubilization and thermodynamic analysis of isotretinoin (ITN) in eleven distinct green solvents, such as water, methyl alcohol (MeOH), ethyl alcohol (EtOH), 1-butyl alcohol (1-BuOH), 2-butyl alcohol (2-BuOH), ethane-1,2-diol (EG), propane-1,2-diol (
Mahdi, Wael A., Alwhaibi, Abdulrahman, Shakeel, Faiyaz, Miteb Alenazi, Faiyaz Shakeel, Haq, Nazrul, Abdulrahman Alwhaibi, Ibrahim A. Alsarra, Alsarra, Ibrahim A., Nazrul Haq, Alshehri, Sultan, Alenazi, Miteb, Sultan Alshehri, Wael A. Mahdi   +13 more
core   +1 more source

Facile and green synthesis of 3,5-disubstituted isoxazoles using doped nano-sized copper(I) oxide (Cu2O) on melamine–formaldehyde resin as an efficient nano-catalyst under ultrasonic irradiation [PDF]

شیمی کاربردی روز, 2019
In the present research, doped nano-sized copper(I) oxide (Cu2O) on melamine–formaldehyde resin as a heterogeneous and efficient nano-catalyst has been employed for green and mild synthesis of 3,5-disubstituted isoxazoles under ultrasonic irradiation. In
Somayeh Behrouz
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Selective recovery of Co(II) over Ni(II), Al(III), and Li(I) from ethylene glycol solution by solvent extraction and precipitation

CTU Journal of Innovation and Sustainable Development
Using “green solvents” like ethylene glycol (EG) to replace water in hydrometallurgical processes is increasingly popular because of its feasibility and environmental friendliness advantages. In this study, the selective recovery behavior of Co(II) over
Viet Nhan Hoa Nguyen, Quoc Vinh Ly, Mong Nhu Y Huynh, Van Hong Thien Doan, Huynh Vu Thanh Luong, Thi Hong Nguyen, Man Seung Lee, Thanh Tuan Tran   +7 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Solvent-free synthesis of photoluminescent carbon nanoparticles from lignin-derived monomers as feedstock

, 2023
Photoluminescent carbon nanoparticles (CNPs), such as carbon dots (CDs), have attracted much attention owing to a unique set of properties, like high and tunable fluorescence.
Márcia G. A. da Cruz (15196986), Adam Slabon (4603525), Bruno V. M. Rodrigues (5089799), Serhiy Budnyk (5002880), Joy N. Onwumere (15196989), Jianhong Chen (1632946), Björn Beele (15196992), Maksym Yarema (1269915)   +7 more
core   +1 more source

Unveiling the Untapped Potential of Bertagnini’s Salts in Microwave-Assisted Synthesis of Quinazolinones

Molecules
Microwave-assisted organic synthesis (MAOS) has emerged as a transformative technique in organic chemistry, significantly enhancing the speed, efficiency, and selectivity of chemical reactions.
Shyamal Kanti Bera, Sourav Behera, Lidia De Luca, Francesco Basoccu, Rita Mocci, Andrea Porcheddu   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source