Results 181 to 190 of about 347,931 (304)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Editorial: The biorefineries and application of green technologies for recovering bioactive compounds from microalgae

Frontiers in Marine Science
Jelena Vladić, Luisa Gouveia
doaj   +1 more source

Ethanol-Assisted Green-Solvent-Based Strategy for Slot-Die Coated Perovskite Solar Cells with over 70% Eco-Friendly Solvent Content. [PDF]

Small
Ahn JW, Kim SY, Jeon SW, Oh OJ, Lee SM, Park JH, Han WC, Kim CY, Kim DH, Woo MY, Kim MJ, Lee KP, Shin CH, Kang DH, Kang S, Noh JH.   +15 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Closed-Loop Recyclable Polyhexahydrotriazine Aerogels Utilizing N,N-Dimethyl Lactamide as a Green Solvent. [PDF]

ChemSusChem
Wang CL, Glišić I, Chen YR, Tomović Ž.   +3 more
europepmc   +1 more source

Green solvent mediated extraction of micro- and nano-plastic particles from water. [PDF]

Sci Rep, 2023
Hunter JR, Qiao Q, Zhang Y, Shao Q, Crofcheck C, Shi J.   +5 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Predicting drug solubility in supercritical carbon dioxide green solvent using machine learning models based on thermodynamic properties. [PDF]

Sci Rep
Sheikhshoaei AH, Sodeifian G.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Enhancing phenolic and flavonoid recovery from Vietnamese balm using green solvent-based ultrasonic-enzymatic-assisted extraction. [PDF]

Ultrason Sonochem
Vo TP, Trang Nguyen TH, Tran Nguyen HB, Nguyen HN, Nhi Le NV, Ha MH, Pham GB, Nguyen DQ.   +7 more
europepmc   +1 more source