Results 101 to 110 of about 153,661 (288)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Green Solvents for Polymer Applications [PDF]

, 2019
Discovery and development of green solvents for large-scale industrial applications is critical to the bioeconomy transition, yet academic solvent research focuses on use of solvents for organic synthesis, creating a knowledge gap in other areas. Polymer
Zhenova, Anna
core  

Exploring the Critical Role of Green Chemistry in Enhancing Sustainability and Efficiency in Pharmaceutical Analytical Testing: Using Chromatographic, Spectrophotometric and Microextraction Techniques [PDF]

Records of Pharmaceutical & Biomedical Sciences
Integrating the green chemistry principles into chromatographic, spectrophotometric and microextraction techniques concepts not only enhances the environmental sustainability of analytical practices but also aligns with the broader goals of reducing ...
Aziza Mostafa, Ahmed Mohammed, Ghada Hadad, Randa Moussa, Mohamed A Abdelshakour   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A scale-up procedure to dialkyl carbonates and their use as green solvents for the preparation of PVDF membranes

, 2022
Dialkyl carbonates (DACs) are well-known green solvents and reagents that have been extensively investigated as safe alternatives to chlorine-based compounds.
Giacomo Trapasso, Claudio Salaris, Fabio Arico, Klaus Kümmerer, James Sherwood, Alberto Figoli, Marco Reich, Evgenia Logunova, Francesco Galiano, Francesca Russo, Con Robert McElroy, Cristiano Salata   +11 more
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Ultrasound-Assisted Extraction of Inorganic Elements and Antioxidants from Gingerbread Cookies Using Natural Deep Eutectic Solvents

Foods
In the present study, ultrasound-assisted extraction using deep eutectic solvents was proposed for the preparation of uniced and iced gingerbread cookies prior to the determination of four macronutrients (potassium, sodium, magnesium, calcium), four ...
Agnieszka Kowaluk, Jean Guédon, Natalia Kryska, Dobrochna Rabiej-Kozioł, Michał Strzelec, Aleksandra Szydłowska-Czerniak   +5 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source